{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T01:54:08Z","timestamp":1781747648096,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T00:00:00Z","timestamp":1064188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study the effects of the atypical antipsychotics quetiapine and olanzapine, and the typical antipsychotic haloperidol on EEG patterns were retrospectively investigated in 81 patients under stable monotherapy with either drug (quetiapine:<jats:italic>n<\/jats:italic>\u2009=\u200922, olanzapine:<jats:italic>n<\/jats:italic>\u2009=\u200937, haloperidol:<jats:italic>n<\/jats:italic>\u2009=\u200922). These three subgroups were compared with a control group of healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u200930) which were matched regarding sex and age. Diagnoses of patients were schizophrenia (DSM\u2010IV 295.xx,<jats:italic>n<\/jats:italic>\u2009=\u200961), brief psychotic disorder (DSM\u2010IV 298.8,<jats:italic>n<\/jats:italic>\u2009=\u20099), schizoaffective disorder (DSM\u2010IV 295.70,<jats:italic>n<\/jats:italic>\u2009=\u20098) and delusional disorder (DSM\u2010IV 297.1,<jats:italic>n<\/jats:italic>\u2009=\u20093). There were no statistically significant differences regarding demographic characteristics between the groups. Digital EEG recordings were retrieved from a database and visually assessed by two independent investigators, and one blinded regarding medication. One patient from the quetiapine group (5%), 13 olanzapine patients (35%), five of the haloperidol patients (23%) and two subjects of the control group (7%) had an abnormal EEG. Epileptiform activity was observed in four patients (11%) of the olanzapine group, and none in the others. EEG abnormalities were statistically significantly increased with dose in the olanzapine group, in contrast to patients treated with haloperidol, quetiapine or healthy subjects. In conclusion, EEG abnormalities seem to occur rarely in patients treated with quetiapine comparable to the control group, but significantly more often with haloperidol and olanzapine, possibly due to different receptor profiles of these substances. To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.537","type":"journal-article","created":{"date-parts":[[2005,1,22]],"date-time":"2005-01-22T00:32:18Z","timestamp":1106353938000},"page":"641-646","source":"Crossref","is-referenced-by-count":72,"title":["EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects"],"prefix":"10.1002","volume":"18","author":[{"given":"Benedikt L.","family":"Amann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pogarell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Mergl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Juckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Grunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Mulert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Hegerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.109"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780010097011"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.111.4.263"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.136.5.445"},{"key":"e_1_2_1_6_1","volume-title":"Atlas of Electroencephalography","author":"Gibbs FA","year":"1964"},{"key":"e_1_2_1_7_1","first-page":"923","article-title":"Electroencephalic study of two hundred and seventy\u2010five candidates for military service","volume":"2","author":"Harty JE","year":"1942","journal-title":"War Med (Chicago)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100861"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8760(92)90078-P"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118419"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/155005949402500309"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb05444.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790060017002"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245455"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000426"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.11.1419"},{"key":"e_1_2_1_17_1","first-page":"385","article-title":"Topographic brain mapping of EEG in neuropsychopharmacology\u2014Part II. 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