{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T05:03:06Z","timestamp":1700283786761},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T00:00:00Z","timestamp":1077580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The atypical antipsychotics are being increasingly used to control acute manic episodes, and data are emerging to support their mood\u2010stabilizing and antidepressant properties. This study investigated the short\u2010term efficacy of quetiapine as an add\u2010on therapy in the treatment of acute mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study was a 4\u2010week, open\u2010label, add\u2010on, prospective investigation using quetiapine in addition to mood stabilizers. Data on 18 patients fulfilling DSM\u2010IV diagnostic criteria for bipolar I disorder were analysed. The Young mania rating scale (YMRS), the Hamilton scale for depression (HDRS), the brief psychiatric rating scale (BPRS) and extrapyramidal symptom rating scale (ESRS) were applied at baseline and at weeks 1, 2 and 4. The clinical global impression scale (CGI) was evaluated at baseline and week 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The addition of quetiapine produced a statistically significant improvement on the YMRS, HDRS, BPRS and CGI score at week 4 from baseline (<jats:italic>p<\/jats:italic>&lt;0.005). Quetiapine was well tolerated, with no subjects discontinuing because of side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of quetiapine was associated with a substantial symptomatic improvement in patients with acute mania. Randomized placebo\u2010controlled prospective studies are needed. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.577","type":"journal-article","created":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T13:44:04Z","timestamp":1080135844000},"page":"181-185","source":"Crossref","is-referenced-by-count":4,"title":["Combination of mood stabilizers with quetiapine for treatment of acute bipolar disorder: an open label study"],"prefix":"10.1002","volume":"19","author":[{"given":"Won\u2010Myong","family":"Bahk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung\u2010Uk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Ho","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,24]]},"reference":[{"issue":"4","key":"e_1_2_1_2_1","first-page":"3","article-title":"Treatment of agitation in bipolar disorder across the life cycle","volume":"64","author":"Alderfer BS","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_3_1","volume-title":"The 27th Nordic Psychiatric Congress August 13\u201316; 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