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Using an animal model of repeated trauma, the effect of stress was investigated on the hippocampal NO\u2010cGMP signalling pathway, specifically the release of nitrogen oxides (NOx) and its modulation by NMDA receptor\u2010, NO\u2010, cGMP\u2010 and nuclear factor K\u2010\u03b2 (NFK\u2010\u03b2)\u2010selective drugs. Immediately after stress, rats received the glutamate NMDA receptor antagonist, memantine (MEM; 5\u2009mg\/kg i.p.\/d), the NO synthase inhibitor, 7\u2010nitroindazole sodium salt (7\u2010NINA; 20\u2009mg\/kg i.p.\/d), the cGMP\u2010specific PDE inhibitor, sildenafil (SIL; 10\u2009mg\/kg i.p.\/d) or the NF\u03ba\u2010\u03b2 antagonist, pyrollidine dithiocarbamate (PDTC; 70\u2009mg\/kg i.p.\/d), for 7 days. Stress significantly increased hippocampal NOx on day 7 post\u2010stress, which was blocked by either 7\u2010NINA or PDTC, while MEM was without effect. SIL, however, significantly augmented stress\u2010induced NOx accumulation. Increased cGMP therefore acts as a protagonist in driving stress\u2010related events, while both nNOS (neuronal NOS) and iNOS (inducible\/immunological NOS) may represent a therapeutic target in preventing the effects of severe stress. The value of NMDA receptor antagonism, however, appears limited in this model. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.695","type":"journal-article","created":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T15:21:15Z","timestamp":1116948075000},"page":"367-373","source":"Crossref","is-referenced-by-count":35,"title":["Involvement of the NMDA receptor, NO\u2010cyclic GMP and nuclear factor K\u2010\u03b2 in an animal model of repeated trauma"],"prefix":"10.1002","volume":"20","author":[{"given":"Brian H.","family":"Harvey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Bothma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u00e9","family":"Nel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregers","family":"Wegener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan 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