{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:02:22Z","timestamp":1788292942597,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a leading cause of mortality worldwide. One of the newer treatments for AD is amyloid beta (A\u03b2) directed monoclonal antibodies (mAbs). This systematic review and meta\u2010analysis aimed to assess the efficacy and safety of this class of drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across Scopus, Web of Science, PubMed, and the Cochrane Library until January 30, 2025, focusing on phase III randomized controlled trials (RCTs) evaluating anti\u2010A\u03b2 mAbs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve RCTs with 24 arms were included. Anti\u2010A\u03b2 mAbs significantly reduced the Clinical Dementia Rating\u2010Sum of Boxes (CDR\u2010SB) score (mean difference (MD): \u22120.16, 95% confidence interval (CI) (\u22120.29, \u22120.04)), Alzheimer's Disease Assessment Scale\u2010Cognitive Subscale (ADAS\u2010Cog) score (MD: \u22120.87, 95% CI (\u22121.13, \u22120.60)), and amyloid positron emission tomography (PET) standardized uptake value ratio (SUVR) (MD: \u22120.11, 95% CI (\u22120.19, \u22120.02)). They also significantly increased the Mini\u2010Mental State Examination (MMSE) score (MD: 0.31, 95% CI (0.15, 0.46)) and Alzheimer's Disease Cooperative Study\u2010Activities of Daily Living (ADCS\u2010ADL) score (MD: 1.21, 95% CI (0.89, 1.53)). However, they were associated with a significant increase in complications, including amyloid\u2010related imaging abnormalities\u2010edema\/effusion (ARIA\u2010E) (odds ratio (OR): 10.20, 95% CI (7.17, 14.50)), ARIA\u2010hemosiderosis or microhemorrhage (ARIA\u2010H) (OR: 1.75, 95% CI (1.22, 2.50)), and any adverse events (OR: 1.22, 95% CI (1.08, 1.38), I\n                      <jats:sup>2<\/jats:sup>\n                      : 48.59%)). The subgroup analysis showed that treatment administered in the early\/preclinical stages of AD resulted in a greater reduction in CDR\u2010SB and ADAS\u2010Cog scores, as well as in amyloid burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010A\u03b2 mAbs offer modest clinical benefits, and pose some serious complications, necessitating a cautious approach to their prescription.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.70017","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T11:39:57Z","timestamp":1757936397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Efficacy and Safety of Amyloid Beta\u2010Directed Monoclonal Antibodies for Alzheimer's Disease: A Systematic Review and Meta\u2010Analysis of Phase III Randomized Controlled Trials"],"prefix":"10.1002","volume":"40","author":[{"given":"Yun","family":"Wei","sequence":"first","affiliation":[{"name":"Medical College Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2099-3607","authenticated-orcid":false,"given":"Hualing","family":"Li","sequence":"additional","affiliation":[{"name":"Medical College Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101339"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2304430"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e318232a379"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100297\u2010z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259\u2010023\u201000633\u20102"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12450"},{"key":"e_1_2_12_9_1","unstructured":"DeeksJ. 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