{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:17:01Z","timestamp":1788160621374,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The paliperidone palmitate 3\u2010month (PP3M) formulation offers an extended dosing interval compared to the 1\u2010month (PP1M) formulation. However, data on the comparative side effect profiles of PP1M versus PP3M in real\u2010world settings remain limited. This study aimed to compare the side effect profiles in patients with schizophrenia receiving PP1M and those who switched from PP1M to PP3M.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Of 473 patients with schizophrenia screened, 132 received long\u2010acting injectable antipsychotics; 67 initiated PP1M, of whom 43 subsequently converted to PP3M and had evaluable data at both time points. The primary analysis used a within\u2010patient mirror\u2010image design (PP1M month\u20104 vs PP3M month\u20104). Side effects were assessed using the UKU Side Effect Rating Scale, and symptom severity was evaluated with the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms, at 4\u00a0months after PP1M initiation and 4\u00a0months after PP3M switch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UKU side\u2010effect profiles were broadly similar after conversion to PP3M, with no increase in the UKU total score. The most frequent side effects for both formulations were increased fatigability, hypokinesia, weight gain, and diminished sexual desire. The frequency of side effects remained mostly stable, with constipation showing a significant decrease after switching. Side effects were more prevalent in patients with schizophrenia using multiple antipsychotics compared to monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this within\u2010patient cohort stabilized on PP1M, conversion to PP3M was not associated with an increase in overall UKU side\u2010effect burden. Selecting the appropriate dose before switching and preferring monotherapy may enhance treatment comfort. These results may help guide clinicians in selecting long\u2010acting injectable antipsychotics in practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.70033","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:31:43Z","timestamp":1767861103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Side Effects Between 3\u2010Monthly and 1\u2010Monthly Paliperidone Palmitate Formulations in Patients With Schizophrenia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-4007","authenticated-orcid":false,"given":"Erkan","family":"Kuru","sequence":"first","affiliation":[{"name":"Private Practice, Psychiatry  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-3280","authenticated-orcid":false,"given":"Ilker","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bursa City Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-7288","authenticated-orcid":false,"given":"Bengu","family":"Yucens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Faculty of Medicine Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-8039","authenticated-orcid":false,"given":"M. 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