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Lithium carbonate can be helpful in moderating the impulsive behaviors associated with mania, possibly mediated by reduced\n                      <jats:italic>myo<\/jats:italic>\n                      \u2010inositol activity following inhibition of the enzyme inositol monophosphatase (IMPase). We tested the hypothesis that impulsivity\u2014as motor disinhibition, decisions without adequate information, and stronger preferences for small immediate rewards over larger later rewards\u2014can be moderated by the IMPase inhibitor ebselen in healthy adult volunteers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and thirty healthy adults completed a between\u2010subjects, double\u2010blind, placebo\u2010controlled protocol. Over 2\u00a0days, participants received a previously validated dose of 1800\u00a0mg of ebselen or placebo before completing tests of impulsivity and decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no substantive changes in any measure of impulsivity following treatment with ebselen compared with placebo. Neither was there any convincing evidence of stronger treatment effects in high\u2010trait impulsive participants compared with low\u2010trait participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results fail to replicate findings that ebselen administration moderates validated measures of impulsivity in healthy adults, at least at doses shown to reduce\n                      <jats:italic>myo<\/jats:italic>\n                      \u2010inositol within the medial prefrontal cortex and produce changes in emotional processing and reward\u2010based learning.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.70040","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:21:32Z","timestamp":1776831692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-5440","authenticated-orcid":false,"given":"Matthew P. 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