{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:04:26Z","timestamp":1779793466960,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n The\n CYP2D6*10<\/jats:italic>\n allele, which is prevalent in the Indian population, is of particular clinical significance. This study aims to investigate the effect of the\n CYP2D6*10<\/jats:italic>\n allele on the pharmacokinetics of risperidone and its metabolites following single\u2010dose administration in healthy South Indian volunteers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study was conducted with twenty healthy volunteers who were administered a single 2\u00a0mg dose of risperidone.\n CYP2D6<\/jats:italic>\n genotyping was performed using the PCR\u2010RFLP method. Plasma levels of risperidone (RIS) and its active metabolite 9\u2010hydroxyrisperidone (9\u2010OHRIS) were quantified using a UPLC\u2010DAD system.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant differences in pharmacokinetic parameters were observed across the\n CYP2D6*10<\/jats:italic>\n genotypes. For intermediate metabolizers, the\n C<\/jats:italic>\n max<\/jats:sub>\n , AUC\n \n 0\u2013\n t<\/jats:italic>\n <\/jats:sub>\n , and\n T<\/jats:italic>\n 1\/2<\/jats:sub>\n were approximately 1.2 times higher, and the metabolic ratio was double compared to normal metabolizers. Notably, the\n C<\/jats:italic>\n max<\/jats:sub>\n of the active moiety was significantly higher in intermediate metabolizers compared to normal metabolizers (\n p<\/jats:italic>\n \u00a0<\u00a00.05). These findings indicate that\n CYP2D6<\/jats:italic>\n polymorphisms are associated with altered pharmacokinetic profiles of risperidone, with a reduced metabolic activation in individuals carrying the *10 allele.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results suggest that\n CYP2D6<\/jats:italic>\n genotyping could help inform personalized dosing strategies for risperidone, though further randomized controlled trials are required to confirm these findings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hup.70044","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:27:06Z","timestamp":1777458426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Influence of\n CYP2D6<\/i>\n on Risperidone Metabolism: Pharmacokinetic and Pharmacodynamic Study in a Healthy South Indian Population"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4124-3490","authenticated-orcid":false,"given":"Ramanujam","family":"Narayanan","sequence":"first","affiliation":[{"name":"Department of Pharmacology PSG Institute of Medical Sciences and Research Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics PSG College of Pharmacy Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-6808","authenticated-orcid":false,"given":"Susipriya","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"PSG\u2010Centre for Molecular Medicine and Therapeutics PSG Institute of Medical Sciences and Research Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ranjithkumar","sequence":"additional","affiliation":[{"name":"Norton Thoracic Institute St. Joseph's Hospital and Medical Center Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaselvakumar","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"PSG\u2010Centre for Molecular Medicine and Therapeutics PSG Institute of Medical Sciences and Research Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010003\u20100657\u20104"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"115","article-title":"Allelic and Genotype Frequencies of Catechol\u2010O\u2010Methyltransferase (Val158Met) and CYP2D6*10 (Pro34Ser) Single Nucleotide Polymorphisms in the Philippines","volume":"3","author":"Baclig M. 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