{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:04:26Z","timestamp":1779793466572,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\u2018Ego dissolution\u2019 refers to a temporary state characterized by diminished self\u2010referential processing, which leads to a breakdown of personal boundaries and an enhanced sense of unity with the environment. Both psychedelics, such as ayahuasca, and contemplative practices, like meditation, have been proposed as mechanisms for modulating the ego. While ayahuasca induces transient self\u2010perception alterations, meditation promotes more sustained changes through cognitive and emotional regulation. This study examines whether ayahuasca consumption modulates the ego and compares its effects with those of meditation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 37 ayahuasca users and 137 meditators participated. We used the \u201cDelusion of Me\u201d (DoM) index, a unidimensional self\u2010report measure comprising three domains: acceptance, decentering, and non\u2010attachment. It could be considered closely related to the concept of self \u2018as a content\u2019 and may potentially serve as a measure of ego.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meditators exhibited significantly higher DoM scores than ayahuasca users. The quadratic regression did not show a cumulative effect, with no significant relationship found between the number of ayahuasca sessions and DoM scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Meditation practice correlated with higher DoM scores and cumulative practice showed a significant non\u2010linear association with DoM. Conversely, repeated ayahuasca exposure demonstrated no evidence of a cumulative association in this sample.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.70046","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:24:56Z","timestamp":1777969496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating Hypo\u2010Egoic Features: Ayahuasca's Psychedelic Path Versus Meditation's Mindful Journey"],"prefix":"10.1002","volume":"41","author":[{"given":"Mar\u00eda","family":"Arqueros","sequence":"first","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010Sant Pau (IIB\u2010SANT PAU)  Barcelona Spain"},{"name":"Department of Psychiatry and Forensic Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010Sant Pau (IIB\u2010SANT PAU)  Barcelona Spain"},{"name":"Department of Psychiatry and Forensic Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausi\u00e0s","family":"Cebolla","sequence":"additional","affiliation":[{"name":"Departamento de Personalidad, Evaluaci\u00f3n y Tratamientos Psicol\u00f3gicos University of Valencia UV  Val\u00e8ncia Spain"},{"name":"CIBER Physiopathology of Obesity and Nutrition (CIBEROBN)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garcia\u2010Campayo","sequence":"additional","affiliation":[{"name":"Miguel Servet Hospital University of Zaragoza  Zaragoza Spain"},{"name":"Red de Investigaci\u00f3n de Actividades Preventivas y Promoci\u00f3n de la Salud (RedIAPP)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Dom\u00ednguez\u2010Clav\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010Sant Pau (IIB\u2010SANT PAU)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental Instituto de Salud Carlos III  Madrid Spain"},{"name":"Mental Health and Psychiatry Department Consorci Hospitalari de Vic Institut de Recerca i Innovaci\u00f3 en Ci\u00e8ncies de la Vida i de la Salut a la Catalunya Central (IRIS\u2010CC)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191105283504"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/rel12080586"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.01.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780199328079.001.0001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671\u2010017\u20100826\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.07.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2807"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.03.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20105085\u20103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166127"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.04.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2006.08.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1047840X.2015.1092493"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787581851"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010006\u20100457\u20105"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691611419671"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nc\/nix016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00269"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000264"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00263"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx036"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00224"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010015\u20104162\u20100"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.659835"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3916"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20104988\u20103"}],"container-title":["Human 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