{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:58:54Z","timestamp":1785131934365,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24zf0127011"],"award-info":[{"award-number":["JP24zf0127011"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K10934"],"award-info":[{"award-number":["23K10934"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10723"],"award-info":[{"award-number":["24K10723"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Insomnia impairs cognitive and brain function, and its treatment improves outcomes. Eye movements are objective biomarkers of neurocognitive state and are sensitive to sleep loss, but whether treatment improves oculomotor function remains unclear. We examined associations between sleep improvement and eye movement changes after hypnotic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open\u2010label, single\u2010arm study, 31 Japanese adults aged \u2265\u00a050\u00a0years with insomnia and preserved cognition received nightly lemborexant (5\u201310\u00a0mg) and were assessed at baseline, week 4, and week 12. Eye movements were measured using free\u2010viewing, smooth pursuit, and fixation tasks. Objective sleep was assessed with a portable electroencephalogram, and subjective sleep and sleepiness with the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Associations were analyzed using linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Improvements in ESS and PSQI scores were associated with enhanced visual search performance in the free\u2010viewing task, including increased saccade amplitude, scanpath length, and velocity. ESS improvement correlated with better tracking accuracy during smooth pursuit, reflected by fewer gaze fixations and saccades. Longer total sleep duration was associated with increased saccade duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Selected eye movement metrics were modestly associated with improvements in subjective sleep symptoms following hypnotic treatment in older adults with insomnia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.70056","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:59:26Z","timestamp":1783151966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Oculomotor Function Following Sleep Improvement With Lemborexant in Older Adults With Insomnia"],"prefix":"10.1002","volume":"41","author":[{"given":"Seiko","family":"Miyata","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kawai","sequence":"additional","affiliation":[{"name":"Pathophysiology of Mental Disorders Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Psychiatry and Psychotherapy Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4862-5889","authenticated-orcid":false,"given":"Ippei","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-1343","authenticated-orcid":false,"given":"Emiko","family":"Shishido","sequence":"additional","affiliation":[{"name":"Section of Brain Function Information National Institute for Physiological Sciences  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-7837","authenticated-orcid":false,"given":"Kenichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry  Kodaira Japan"},{"name":"Institute for the Advanced Study of Human Biology Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Medical Headquarters Eisai Co., Ltd.  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