{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:06Z","timestamp":1786977906995,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T00:00:00Z","timestamp":1143158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated the acute effects of alcohol on neurophysiological and psychomotor functions and the subjective response in healthy young Korean men according to the mitochondrial aldehyde dehydrogenase (ALDH2) genotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 24 males, half with ALDH2*1\/*1 (active form) and the rest with ALDH2*1\/*2 (inactive form), were selected through genotyping. In a double\u2010blind placebo\u2010controlled crossover design, each subject consumed either a 0.5\u2009g\/kg dose of alcohol or a placebo on two separate occasions, 1 week apart. The blood alcohol concentrations (BACs), P300 of event\u2010related potential, psychomotor performance, and perceived feelings were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although the BACs were similar between the two groups, the effects of alcohol on P300 were greater overall in subjects with ALDH2*1\/*2 than in subjects with ALDH2*1\/*1. Psychomotor performance was more impaired after alcohol ingestion in subjects with ALDH2*1\/*2 than in subjects with ALDH2*1\/*1. The subjective response after alcohol ingestion was more negative in subjects with ALDH2*1\/*2, compared to subjects with ALDH2*1\/*1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that the ALDH2 polymorphism is an important factor in determining the effects of alcohol on various psychobehavioral functions. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.755","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T13:16:41Z","timestamp":1143206201000},"page":"159-166","source":"Crossref","is-referenced-by-count":10,"title":["ALDH2 genotype\u2010associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double\u2010blind placebo\u2010controlled crossover 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