{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:42:27Z","timestamp":1760384547770},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T00:00:00Z","timestamp":1145404800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bipolar disorder (BPD) is often comorbid with obsessive\u2010compulsive (OCD) and other anxiety disorders, but the impact of such comorbidity on long\u2010term outcome has not been evaluated systematically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extensive follow\u2010up assessments were carried out at 4.3 years after index hospitalizations in a mixed BPD\u2010OCD group (<jats:italic>N<\/jats:italic>\u2009=\u200920) compared to matched groups with BPD (<jats:italic>N<\/jats:italic>\u2009=\u200922) or OCD (<jats:italic>N<\/jats:italic>\u2009=\u200920) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up, ratings of functional status were similar across groups. Rehospitalizations were similar among BPD\u2010OCD and BPD subjects, but 2.9\u2010times more frequent among comorbid than OCD patients. OCD symptoms averaged 150% more severe in OCD than comorbid subjects, and were not measured in BPD subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite potential sampling bias with previously hospitalized subjects, the findings suggest that comorbid BPD\u2010OCD patients may be clinically more similar to BPD than OCD patients, and that BPD\u2010OCD comorbidity may not negatively impact the long\u2010term clinical outcome. 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