{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:20:05Z","timestamp":1791357605036,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study documents the incidences of agranulocytosis and neutropenia, and the patterns of incidence of the side effects of long\u2010term clozapine treatment in order to determine an appropriate time to stop the Clozaril Patient Monitoring System (CPMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hematological, demographic, and other data from the CPMS for 6782 patients who took clozapine for the past 11 years in the Republic of Korea has been analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine (53.7%) of fifty\u2010four agranulocytosis cases occurred within the first 18 weeks. The cumulative incidence of agranulocytosis was 1.64% between 6 and 11 years and the crude incidence was 0.8%. Neutropenia occurred in 697 patients, and 365 (52.4%) of these cases occurred within the first 18 weeks. The cumulative incidence of neutropenia was 19.8% between 8 and 11 years, and the crude incidence was 10.3%. There were no cases of agranulocytosis or neutropenia after the 9th year of clozapine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of agranulocytosis in the Republic of Korea was similar to those in the rest of the world. While agranulocytosis began several years after clozapine treatment, long\u2010term monitoring of white blood cells is necessary. We suggest that the CPMS should be stopped or less frequently after the 9th year of treatment. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.779","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T02:46:24Z","timestamp":1155869184000},"page":"387-391","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010term patient monitoring for clozapine\u2010induced agranulocytosis and neutropenia in Korea: when is it safe to discontinue CPMS?"],"prefix":"10.1002","volume":"21","author":[{"given":"Byung\u2010Jo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Je","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Tae","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beang\u2010Jin","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewook","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.4.483"},{"key":"e_1_2_1_4_1","first-page":"53","volume-title":"Side Effects of Drugs, Annual 26","author":"Carvajal A","year":"2003"},{"key":"e_1_2_1_5_1","first-page":"166","article-title":"Agranulocytosis and neutropenia in clozapine\u2010treated patients","volume":"10","author":"Cho HS","year":"1999","journal-title":"Korean J Psychopharmacol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb141414.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb04786.x"},{"key":"e_1_2_1_8_1","first-page":"287","article-title":"Transient neutropenia induced by clozapine","volume":"28","author":"Hummer M","year":"1992","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_1_9_1","first-page":"429","article-title":"Clozapine\u2010induced transient white blood cell disorders","volume":"55","author":"Hummer M","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1192\/S0007125000296906","article-title":"Clozapine\u2010associated agranulocytosis: risk and aetiology","volume":"160","author":"Krupp P","year":"1992","journal-title":"Br J Psychiatry"},{"key":"e_1_2_1_11_1","first-page":"233","article-title":"Blood dyscrasias in clozapine\u2010treated patients in Italy","volume":"85","author":"Lambertenghi DG","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810220061007"},{"key":"e_1_2_1_13_1","first-page":"2008","volume-title":"Physicians' Desk Reference","year":"2000"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442568"},{"key":"e_1_2_1_15_1","first-page":"1096","volume-title":"The Textbook of Clinical Psychiatry","author":"Robert EH","year":"2003"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T07:11:36Z","timestamp":1700032296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,19]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1002\/hup.779"],"URL":"https:\/\/doi.org\/10.1002\/hup.779","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,19]]}}}