{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:58:18Z","timestamp":1772035098054,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T00:00:00Z","timestamp":1187654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of intramuscular (IM) olanzapine in severely agitated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an open\u2010label multicenter 1\u2010week observational study of IM olanzapine treatment in severely agitated inpatients and psychiatric emergency services with bipolar mania (<jats:italic>n<\/jats:italic>\u2009=\u200922) or schizophrenia (<jats:italic>n<\/jats:italic>\u2009=\u200952). Mean change from baseline to 2\u2009h post\u2010first injection (LOCF) in agitation was assessed by PANSS\u2010Excited Component (PANSS\u2010EC) (score range: 5\u201335 points) mean change from baseline to 15, 30, 45, 60, 90, and 120\u2009min post\u2010first injection, and visit\u2010wise mean changes from mixed\u2010model repeated measures analysis of variance. Kaplan\u2013Meier survival curve analyses estimated time to categorical response (rating of \u22643 points each PANSS\u2010EC item).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hours post\u2010injection of olanzapine (mean dose\u2009=\u20099.9\u2009mg), patients exhibited mild calmness and agitation was significantly reduced by 19.2\u2009\u00b1\u20091.0 points (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) (mean baseline\u2009=\u200929.0). Over 90% of the patients received only one injection in the first 24\u2009h and 50% had a categorical response within 30\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severely agitated patients responded rapidly after a single injection of olanzapine with mild levels of sedation and without serious treatment\u2010emergent adverse events. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.870","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T08:47:05Z","timestamp":1187686025000},"page":"455-462","source":"Crossref","is-referenced-by-count":30,"title":["An observational study of the effectiveness and safety of intramuscular olanzapine in the treatment of acute agitation in patients with bipolar mania or schizophrenia\/schizoaffective disorder"],"prefix":"10.1002","volume":"22","author":[{"given":"Franca","family":"Centorrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam L.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonna","family":"Ahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Cincotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Zun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela H.","family":"Gulliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce J.","family":"Kinon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Houston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Expert Concensus guideline series. 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