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However, escitalopram was associated with statistically significant reductions in weight, body mass index (BMI), and global severity of illness scores. In a secondary analysis, escitalopram was associated with statistically significant reductions in frequency of binge episodes and binge days, weight, BMI and severity of illness, but not in obsessive\u2010compulsive symptoms of BED. No changes in metabolic variables, including measures of ghrelin and leptin, were observed. High\u2010dose escitalopram was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose escitalopram was not efficacious in reducing obsessive\u2010compulsive symptoms of BED, but was efficacious in reducing weight and global severity of illness. No definitive conclusions about its efficacy in reducing binge\u2010eating frequency could be drawn due to limitations related to statistical power. 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