{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:46:13Z","timestamp":1791477973722,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T00:00:00Z","timestamp":1196640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Since sustained treatment\u2010adherence is often problematic and may limit clinical outcomes among bipolar disorder (BPD) patients, we sought risk factors to guide clinical prediction of nonadherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were from a 2005 US national sample providing questionnaire responses by 131 randomly selected prescribing psychiatrists and their adult BPD patients. We contrasted demographic and clinical factors in treatment\u2010adherent versus nonadherent patients (strictly defined as missing \u22651 dose within 10 days) in univariate analyses followed by multivariate logistic\u2010regression modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 429 DSM\u2010IV BPD patients (79% type\u2010I; 62% women; 17% minorities), 34% reported missing\u2009\u2265\u20091 dose of psychotropic medication within 10 days, 20% missed entire daily doses at least once, and only 2.5% missed all doses for 10 days. However, their prescribing psychiatrists considered only 6% as treatment\u2010nonadherent. Factors significantly associated with nonadherence in multivariate modeling ranked:\n                      <jats:italic>alcohol\u2010dependence<\/jats:italic>\n                      \u2009&gt;\u2009\n                      <jats:italic>youth<\/jats:italic>\n                      \u2009&gt;\u2009\n                      <jats:italic>greater affective morbidity<\/jats:italic>\n                      \u2009&gt;\u2009various\n                      <jats:italic>side effects<\/jats:italic>\n                      \u2009\u2265\u2009comorbid\n                      <jats:italic>obsessive\u2010compulsive disorder<\/jats:italic>\n                      \u2009\u2265\u2009\n                      <jats:italic>recovering from mania\u2010hypomania<\/jats:italic>\n                      . Unrelated were sex, diagnostic subtype, and other comorbidities. Since most patients received\u2009\u2265\u20092 psychotropics, potential relationships between treatment\u2010complexity and adherence were obscured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalent treatment\u2010nonadherence among American BPD patients, and striking underestimation of the problem by prescribing clinicians may encourage increasingly complex treatment\u2010regimens of untested value, but added expense, risk of adverse effects, and uncertain impact on treatment\u2010adherence itself. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.908","type":"journal-article","created":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T08:16:50Z","timestamp":1196669810000},"page":"95-105","source":"Crossref","is-referenced-by-count":148,"title":["Factors associated with treatment nonadherence among US bipolar disorder patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Ross 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