{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:28:00Z","timestamp":1789993680046,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effects of antidepressants on driving performance from a different methodological viewpoint in light of the recent traffic accidents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blinded, 3\u2010way crossover trial, 17 healthy males received acute doses of 10\u2009mg paroxetine, 25\u2009mg amitriptyline, and placebo. The subjects were administered three driving tasks\u2014road tracking, car following, and harsh braking\u2014performed using a driving simulator and three cognitive tasks\u2014Wisconsin Card Sorting Test, Continuous Performance Test, and N\u2010back test at baseline and at 1\u2009h and 4\u2009h post\u2010dosing. The Stanford Sleepiness Scale scores were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u2009h post\u2010dosing, amitriptyline significantly impaired road\u2010tracking and car\u2010following performance, reduced driver vigilance, and caused subjective somnolence. Paroxetine impaired neither driving performance nor cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute doses of amitriptyline significantly impaired driving performance in the context of driving on crowded urban roads at relatively low speeds. This setting is important with respect to skills necessary for daily driving and may be difficult to measure in actual driving tests. This simulator\u2010based study replicated the results of previous studies and could be considered complementary to them. This method may enable easy and safe screening of the driving hazard potential of drugs. 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