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Measures of information processing and psychomotor performance (choice reaction time, critical flicker fusion, digit symbol substitution, compensatory tracking, body sway), memory (immediate and delayed word recall), and daytime sleepiness (Multiple Sleep Latency Test), as well as subjective ratings (line analog rating scales, Leeds Sleep Evaluation Questionnaire), were obtained starting at 07:00\u2009h the following morning. Adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gaboxadol did not show next\u2010day impairments versus placebo on any pharmacodynamic measures whereas the positive control, flurazepam, did show impairments versus placebo on most measures. Gaboxadol showed improvements versus placebo on some measures including subjective rating of next\u2010day alertness\/clumsiness on the Leeds Sleep Evaluation Questionnaire. Gaboxadol was generally well\u2010tolerated; there were no serious adverse experiences and no subjects discontinued due to an adverse experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single oral bedtime dose of gaboxadol 10\u2009mg did not have next\u2010day residual effects in healthy elderly subjects, as measured by a range of pharmacodynamic assessments, in contrast to the clear impairments produced by flurazepam 30\u2009mg. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.986","type":"journal-article","created":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T09:46:27Z","timestamp":1225791987000},"page":"61-71","source":"Crossref","is-referenced-by-count":14,"title":["Next\u2010day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double\u2010blind study in healthy elderly 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