{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:10:12Z","timestamp":1696655412924},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Data from several studies suggest that oxidative stress may play a role in the pathophysiology of tardive dyskinesia (TD). Glutathione S\u2010transferase (GST) enzymes play important roles in protecting cells against oxidative stress. In the present study, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes can influence susceptibility to TD in patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The GST\u2010M1, GST\u2010T1, and GST\u2010P1 loci were analyzed by polymerase chain reaction (PCR)\u2010based methods in 83 schizophrenic patients with TD and 126 schizophrenic without TD who were matched for antipsychotic drug exposure and other relevant variables. The multifactor dimensionality reduction (MDR) approach was used to analyze gene\u2013gene interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the distributions of the GST\u2010M1, GST\u2010T1, and GST\u2010P1 genotypes between the TD and non\u2010TD groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, in comparison of the severity of TD among genotypes using Poisson regression showed that Ile\/Ile genotype of GST\u2010P1 had higher AIMS score compared to Ile\/Val\u2009+\u2009Val\/Val genotypes (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20097.13, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). MDR analysis did not show a significant interaction between the three GST gene variants and susceptibility to TD (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that GST gene polymorphisms do not confer increased susceptibility to TD in patients with schizophrenia but TD severity might be related with GST\u2010P1 variants. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.988","type":"journal-article","created":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T15:15:47Z","timestamp":1228230947000},"page":"55-60","source":"Crossref","is-referenced-by-count":22,"title":["Association study between glutathione S\u2010transferase GST\u2010M1, GST\u2010T1, and GST\u2010P1 polymorphisms and tardive 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