{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:22:37Z","timestamp":1792714957346,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammatory Bowel Diseases"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1002\/ibd.20225","type":"journal-article","created":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T15:19:31Z","timestamp":1184599171000},"page":"1323-1332","source":"Crossref","is-referenced-by-count":406,"title":["Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor \u03b1 agents"],"prefix":"10.1093","volume":"13","author":[{"given":"Andrew","family":"Nesbitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Bergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roly","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"R1-1-20130704","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0016-5085(99)70332-X","volume":"117","author":"Rutgeerts","year":"1999","journal-title":"Gastroenterology"},{"key":"R2-1-20130704","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/gast.2001.28674","volume":"121","author":"Sandborn","year":"2001","journal-title":"Gastroenterology"},{"key":"R3-1-20130704","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1053\/gast.2001.28702","volume":"121","author":"Lugering","year":"2001","journal-title":"Gastroenterology"},{"key":"R4-1-20130704","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2036.2005.02309.x","volume":"21","author":"Shen","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"R5-1-20130704","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/S0016-5085(03)00382-2","volume":"124","author":"Van den Brande","year":"2003","journal-title":"Gastroenterology"},{"key":"R6-1-20130704","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/gut.50.2.206","volume":"50","author":"ten Hove","year":"2002","journal-title":"Gut"},{"key":"R7-1-20130704","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/cyto.1995.0029","volume":"7","author":"Scallon","year":"1995","journal-title":"Cytokine"},{"key":"R8-1-20130704","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cyto.2004.06.008","volume":"28","author":"Kirchner","year":"2004","journal-title":"Cytokine"},{"key":"R9-1-20130704","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nbt0292-169","volume":"10","author":"Bebbington","year":"1992","journal-title":"Biotechnology"},{"key":"R10-1-20130704","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2005.09.006","volume":"25","author":"Feldmann","year":"2005","journal-title":"J Autoimmun"},{"key":"R13-1-20130704","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"key":"R15-1-20130704","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0092-8674(95)90192-2","volume":"83","author":"Grell","year":"1995","journal-title":"Cell"},{"key":"R16-1-20130704","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1124\/jpet.301.2.418","volume":"301","author":"Scallon","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"R17-1-20130704","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1053\/j.gastro.2004.01.036","volume":"126","author":"Mitoma","year":"2004","journal-title":"Gastroenterology"},{"key":"R18-1-20130704","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1136\/gut.2004.040824","volume":"53","author":"Peppelenbosch","year":"2004","journal-title":"Gut"},{"key":"R19-1-20130704","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/00054725-200411000-00015","volume":"10","author":"Ringheanu","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"R20-1-20130704","first-page":"70","volume":"53","author":"Di Sabatino","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"R21-1-20130704","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1020543625282","volume":"19","author":"Ohshima","year":"1999","journal-title":"J Clin Immunol"},{"key":"R22-1-20130704","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.4049\/jimmunol.156.4.1646","volume":"156","author":"Lorenz","year":"1996","journal-title":"J Immunol"},{"key":"R23-1-20130704","first-page":"304","volume":"27","author":"Lorenz","year":"2000","journal-title":"J Rheumatol"},{"key":"R24-1-20130704","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1182\/blood.V88.2.690.bloodjournal882690","volume":"88","author":"Balazovich","year":"1996","journal-title":"Blood"},{"key":"R25-1-20130704","first-page":"232","volume":"30","author":"den Broeder","year":"2003","journal-title":"J Rheumatol"},{"key":"R26-1-20130704","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.imbio.2004.09.008","volume":"209","author":"Hartmann","year":"2005","journal-title":"Immunobiology"},{"key":"R27-1-20130704","doi-asserted-by":"crossref","first-page":"R250","DOI":"10.1186\/ar1477","volume":"7","author":"Capsoni","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"R28-1-20130704","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/clim.2001.5183","volume":"103","author":"Moreland","year":"2002","journal-title":"Clin Immunol"},{"key":"R29-1-20130704","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/01.meg.0000108344.41221.8b","volume":"16","author":"Agnholt","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R30-1-20130704","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(94)90372-7","volume":"76","author":"Smith","year":"1994","journal-title":"Cell"},{"key":"R31-1-20130704","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/emboj\/18.8.2119","volume":"18","author":"Watts","year":"1999","journal-title":"EMBO J"},{"key":"R32-1-20130704","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.4049\/jimmunol.164.12.6193","volume":"164","author":"Eissner","year":"2000","journal-title":"J Immunol"},{"key":"R33-1-20130704","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1056\/NEJMp048253","volume":"351","author":"Cominelli","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T06:51:59Z","timestamp":1683960719000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/13\/11\/1323-1332\/4652888"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":30,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.1002\/ibd.20225","relation":{},"ISSN":["1078-0998"],"issn-type":[{"value":"1078-0998","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}