{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:30:17Z","timestamp":1790789417575,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammatory Bowel Diseases"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1002\/ibd.21565","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T13:36:25Z","timestamp":1292592985000},"page":"1925-1935","source":"Crossref","is-referenced-by-count":107,"title":["Treatment of colitis with a commensal gut bacterium engineered to secrete human tgf-\u03b21 under the control of dietary xylan"],"prefix":"10.1093","volume":"17","author":[{"given":"Zaed Z.R.","family":"Hamady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenu","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Dilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence R.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Thorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith T.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.A.","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Carding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"R1-11-20130704","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","volume":"126","author":"Loftus","year":"2004","journal-title":"Gastroenterology"},{"key":"R2-11-20130704","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"R3-11-20130704","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.3748\/wjg.14.4280","volume":"14","author":"SanchezMunoz","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R4-11-20130704","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1038\/mi.2008.55","volume":"1","author":"Monteleone","year":"2008","journal-title":"Mucosal Immunol"},{"key":"R5-11-20130704","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.86.5.1578","volume":"86","author":"Barnard","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R6-11-20130704","doi-asserted-by":"crossref","first-page":"23851","DOI":"10.1074\/jbc.M300075200","volume":"278","author":"Haller","year":"2003","journal-title":"J Biol Chem"},{"key":"R7-11-20130704","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1172\/JCI115256","volume":"87","author":"Suemori","year":"1991","journal-title":"J Clin Invest"},{"key":"R8-11-20130704","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.it.2004.07.008","volume":"25","author":"Monteleone","year":"2004","journal-title":"Trends Immunol"},{"key":"R9-11-20130704","first-page":"3","volume":"143","author":"Kulkarni","year":"1993","journal-title":"Am J Pathol"},{"key":"R10-11-20130704","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.188.10.1929","volume":"188","author":"Boirivant","year":"1998","journal-title":"J Exp Med"},{"key":"R11-11-20130704","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1084\/jem.183.6.2605","volume":"183","author":"Neurath","year":"1996","journal-title":"J Exp Med"},{"key":"R12-11-20130704","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1084\/jem.183.6.2669","volume":"183","author":"Powrie","year":"1996","journal-title":"J Exp Med"},{"key":"R13-11-20130704","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0016-5085(93)90014-4","volume":"105","author":"Ciacci","year":"1993","journal-title":"Gastroenterology"},{"key":"R14-11-20130704","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","volume":"16","author":"Letterio","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"R15-11-20130704","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/gut.2007.130922","volume":"57","author":"Di Sabatino","year":"2008","journal-title":"Gut"},{"key":"R16-11-20130704","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","volume":"198","author":"Chen","year":"2003","journal-title":"J Exp Med"},{"key":"R17-11-20130704","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cytogfr.2005.09.004","volume":"17","author":"Becker","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"R18-11-20130704","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1172\/JCI114932","volume":"86","author":"Wakefield","year":"1990","journal-title":"J Clin Invest"},{"key":"R19-11-20130704","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0959-437X(01)00259-3","volume":"12","author":"Wakefield","year":"2002","journal-title":"Curr Opin Gene Dev"},{"key":"R20-11-20130704","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.192.1.41","volume":"192","author":"Kitani","year":"2000","journal-title":"J Exp Med"},{"key":"R21-11-20130704","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.cgh.2006.03.028","volume":"4","author":"Braat","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R22-11-20130704","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","volume":"289","author":"Steidler","year":"2000","journal-title":"Science"},{"key":"R23-11-20130704","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1128\/IAI.66.7.3183-3189.1998","volume":"66","author":"Steidler","year":"1998","journal-title":"Infect Immun"},{"key":"R24-11-20130704","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1128\/AEM.61.4.1627-1629.1995","volume":"61","author":"Steidler","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"R25-11-20130704","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1574-6968.1993.tb05864.x","volume":"10","author":"Thompson","year":"1993","journal-title":"FEMS Microbiol Rev"},{"key":"R26-11-20130704","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.3168\/jds.S0022-0302(90)78988-6","volume":"73","author":"Hespell","year":"1990","journal-title":"J Dairy Sci"},{"key":"R28-11-20130704","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1099\/mic.0.2008\/019109-0","volume":"154","author":"Hamady","year":"2008","journal-title":"Microbiology"},{"key":"R29-11-20130704","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1128\/AEM.58.5.1541-1548.1992","volume":"58","author":"Valentine","year":"1992","journal-title":"Appl Environ Microbiol"},{"key":"R30-11-20130704","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.2042-7158.2003.tb02435.x","volume":"55","author":"GreenwoodVan Meerveld","year":"2003","journal-title":"J Pharm Pharmacol"},{"key":"R31-11-20130704","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/AEM.53.12.2849-2853.1987","volume":"53","author":"Hespell","year":"1987","journal-title":"Appl Environ Microbiol"},{"key":"R32-11-20130704","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1210\/me.6.10.1691","volume":"6","author":"Brunner","year":"1992","journal-title":"Mol Endocrinol"},{"key":"R33-11-20130704","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1073\/pnas.80.12.3676","volume":"80","author":"Frolik","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R34-11-20130704","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0016-5085(94)90803-6","volume":"107","author":"Dieleman","year":"1994","journal-title":"Gastroenterology"},{"key":"R35-11-20130704","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nbt840","volume":"21","author":"Steidler","year":"2003","journal-title":"Nat Biotech"},{"key":"R36-11-20130704","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/AEM.45.3.1025-1033.1983","volume":"45","author":"Croucher","year":"1983","journal-title":"Appl Environ Microbiol"},{"key":"R37-11-20130704","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1053\/gast.1996.v110.pm8613031","volume":"110","author":"Babyatsky","year":"1996","journal-title":"Gastroenterology"},{"key":"R38-11-20130704","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI12821","volume":"108","author":"Monteleone","year":"2001","journal-title":"J Clin Invest"},{"key":"R39-11-20130704","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.92.7.2572","volume":"92","author":"Sanderson","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R40-11-20130704","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1242\/jcs.108.3.985","volume":"108","author":"Shah","year":"1995","journal-title":"J Cell Sci"},{"key":"R41-11-20130704","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1210\/mend-3-12-1977","volume":"3","author":"Graycar","year":"1989","journal-title":"Mol Endocrinol"},{"key":"R42-11-20130704","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.165.9.4773","volume":"165","author":"Gorelik","year":"2000","journal-title":"J Immunol"},{"key":"R43-11-20130704","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1084\/jem.20012076","volume":"195","author":"Gorelik","year":"2002","journal-title":"J Exp Med"},{"key":"R44-11-20130704","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.procbio.2006.05.011","volume":"41","author":"Moure","year":"2006","journal-title":"Process Biochem"},{"key":"R45-11-20130704","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.56.3.3","volume":"56","author":"Simmons","year":"2004","journal-title":"Pharmacol Rev"},{"key":"R46-11-20130704","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI6899","volume":"105","author":"Morteau","year":"2000","journal-title":"J Clin Invest"},{"key":"R47-11-20130704","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1172\/JCI119296","volume":"99","author":"Cohn","year":"1997","journal-title":"J Clin Invest"},{"key":"R48-11-20130704","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/bjp.2008.137","volume":"154","author":"Islam","year":"2008","journal-title":"Br J Pharmacol"},{"key":"R49-11-20130704","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1053\/j.gastro.2005.01.006","volume":"128","author":"Matsuura","year":"2005","journal-title":"Gastroenterology"},{"key":"R50-11-20130704","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.intimp.2006.11.006","volume":"7","author":"CamachoBarquero","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"R51-11-20130704","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrm1203","volume":"4","author":"Taupin","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R52-11-20130704","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/gast.1996.v111.pm8898639","volume":"111","author":"Halttunen","year":"1996","journal-title":"Gastroenterology"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T16:21:18Z","timestamp":1636993278000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/17\/9\/1925-1935\/4633795"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":51,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.1002\/ibd.21565","relation":{},"ISSN":["1078-0998"],"issn-type":[{"value":"1078-0998","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}