{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:24:13Z","timestamp":1787772253308,"version":"build-2784847793"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spinal cord injury (SCI) is a severe disabling disease, which mainly manifests as impairments of sensory and motor functions, sexual function, bladder and intestinal functions, respiratory and cardiac functions below the injury plane. In addition, the condition has a profound effect on the mental health of patients, which often results in severe sequelae. Some patients may be paraplegic for life or even die, which places a huge burden on the family and society. There is still no effective treatment for SCI. Studies have confirmed that endogenous neural stem cells (ENSCs), as multipotent neural stem cells, which are located in the ependymal region of the central canal of the adult mammalian spinal cord, are activated after SCI and then differentiate into various nerve cells to promote endogenous repair and regeneration. However, the central canal of the spinal cord is often occluded to varying degrees in adults, and residual ependymal cells cannot be activated and do not proliferate after SCI. Besides, the destruction of the microenvironment after SCI is also an important factor that affects the proliferation and differentiation of ENSCs and spinal cord repair. Therefore, this review describes the role of ENSCs in SCI, in terms of the origin, transformation, treatment, and influencing factors, to provide new ideas for clinical treatment of SCI.<\/jats:p>","DOI":"10.1002\/ibra.12048","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T09:28:15Z","timestamp":1654334895000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Research progress of endogenous neural stem cells in spinal cord injury"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-8701","authenticated-orcid":false,"given":"Ya\u2010Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-5662","authenticated-orcid":false,"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.12.008"},{"issue":"1509","key":"e_1_2_13_3_1","first-page":"47","article-title":"Epidemiology of traumatic in New Zealand (2007\u20132016)","volume":"133","author":"Mitchell J","year":"2020","journal-title":"N Z Med J"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.123"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2301-z"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","unstructured":"The National Spinal Cord Injury Statistical Center and the Model Systems Knowledge Translation Center. Spinal cord injury (SCI) facts Q5 and figures at a glance. J Spinal Cord Med.2016;39(4):493\u2010494.doi:10.1080\/10790268.2016.1210925","DOI":"10.1080\/10790268.2016.1210925"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0984-1"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20170048"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2019.01241"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.06.007"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12084"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22851"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2853650"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1958631"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01151"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.186"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3065"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815618438"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.09.007"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050982"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv089"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5151"},{"issue":"7","key":"e_1_2_13_24_1","first-page":"751","article-title":"Pathophysiology of neurodegeneration following traumatic brain injury","volume":"61","author":"Freire MA","year":"2012","journal-title":"West Indian Med J"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02968-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.10.011"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0205-2"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270895"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406795101"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0171-16.2017"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.02.038"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aa6450"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2409-16.2017"},{"key":"e_1_2_13_34_1","doi-asserted-by":"crossref","unstructured":"ChioJCT PunjaniN HejratiN ZavvarianMM HongJ FehlingsMG.Extracellular matrix and oxidative stress following traumatic spinal cord injury: physiological and pathophysiological roles and opportunities for therapeutic intervention.Antioxid Redox Signal. Published online December 7 2021;\u00a0doi:10.1089\/ars.2021.0120","DOI":"10.1089\/ars.2021.0120"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.014"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12114"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19638"},{"issue":"1","key":"e_1_2_13_38_1","first-page":"191","article-title":"Expression and clinical significance of Nestin in astrocytic tumors","volume":"21","author":"Fang BJ","year":"2016","journal-title":"J\u00a0BUON"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy284"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90148-1"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1930-0"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082134"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.10.001"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.103"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.026"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.11.003"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36414"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00129-8"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-017-9217-2"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.04.025"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13140"},{"issue":"8","key":"e_1_2_13_52_1","first-page":"830","article-title":"[Effects of different melatonin treatment regimens on the proliferation of endogenous neural stem cells in neonatal rats with hypoxic\u2010ischemic brain damage]","volume":"21","author":"Chen W","year":"2019","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15022207"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.12.SPINE17669"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1835"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00223"},{"issue":"15","key":"e_1_2_13_57_1","first-page":"1138","article-title":"Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats","volume":"7","author":"Wu H","year":"2012","journal-title":"Neural Regen Res"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002302"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.05.027"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119941"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476278.2017.1329789"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.01.009"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM00449B"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001896"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00363G"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102428"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ab785f"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04609"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120596"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.12.032"}],"container-title":["Ibrain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.12048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ibra.12048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.12048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T10:32:16Z","timestamp":1713609136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ibra.12048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/ibra.12048"],"URL":"https:\/\/doi.org\/10.1002\/ibra.12048","archive":["Portico"],"relation":{},"ISSN":["2313-1934","2769-2795"],"issn-type":[{"value":"2313-1934","type":"print"},{"value":"2769-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}