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Numerous neuroanatomical investigations on autistic children have revealed that their brains grow atypically, resulting in atypical neurogenesis, neuronal migration, maturation, differentiation, and degeneration. Special education programs, speech therapy, and occupational therapy have all been used to address autism\u2010related behavioral problems. While widely prescribed antidepressant drugs, antipsychotics, anticonvulsants, and stimulants have demonstrated response in autistic individuals. However, these medications do not fully reverse the core symptoms associated with autism spectrum disorder (ASD). The adverse reactions of ASD medicines and an increased risk of developing various other problems, such as obesity, dyslipidemia, diabetes mellitus, and thyroid disorders, prompted the researchers to investigate herbal medicines for the treatment of autistic individuals. Clinical trials are now being done to establish the efficacy of alternative techniques based on natural substances and to understand better the context in which they may be used to treat autism. This review of literature will look at crucial natural compounds derived from animals and plants that have shown promise as safe and effective autism treatment strategies.<\/jats:p>","DOI":"10.1002\/ibra.12050","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:53:58Z","timestamp":1655787238000},"page":"365-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Potential natural products for the management of autism spectrum disorder"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9967-1872","authenticated-orcid":false,"given":"Punya","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Amity Institute of Neuropsychology and Neurosciences Amity University Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Intizaar","family":"Mehdi","sequence":"additional","affiliation":[{"name":"School of Studies in Neuroscience Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Kaith","sequence":"additional","affiliation":[{"name":"School of Studies in Neuroscience Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medical Elementology and Toxicology Jamia Hamdard University Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Sheeraz","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Campania Luigi Vanvitelli Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","first-page":"421","article-title":"Etude de l'\u00e9volution de onze enfants autistes initialement rapport\u00e9e en 1943 [Follow\u2010up study of eleven autistic children originally reported in 1943. 1971]","volume":"38","author":"Kanner L","year":"1995","journal-title":"Psychiatr Enfant"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901612010120"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.239"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171400172X"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4161"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819e7203"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0121-4"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.06.004"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt282"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-4651.200297"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.e472"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30078"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000278"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12141"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.76"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.98"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708506104"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1994.tb02300.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199003000-00004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4942"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000713"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004415"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21369"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.040"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470869380.ch8"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.06.010"},{"issue":"1","key":"e_1_2_13_28_1","first-page":"1","article-title":"How nutritional status, diet and dietary supplements can affect autism. 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