{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:32:52Z","timestamp":1783006372048,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine the values of the half\u2010effective dose (ED<jats:sub>50<\/jats:sub>) and 95% effective dose (ED<jats:sub>95<\/jats:sub>) of remimazolam besylate used in the procedural sedation of endoscopic retrograde cholangiopancreatography\u00a0(ERCP). Sixty patients who fulfilled the inclusion and exclusion criteria of this study were selected. Sufentanil was administered intravenously and remimazolam besylate was administered 2\u2009min later. ERCP treatment was feasible when the modified alertness\/sedation (MOAA\/S) score was \u22642. If choking or movement occurred during duodenoscope placement, it was considered as a positive reaction. The dose was increased in the next patient; otherwise, it was considered as a negative reaction, and the dose was reduced in the next patient. The ED<jats:sub>50<\/jats:sub> and ED<jats:sub>95<\/jats:sub> values and 95% confidence interval (CI) of remimazolam besylate were calculated by Probit regression analysis. All 60 patients completed the trial. The ED<jats:sub>50<\/jats:sub> and ED<jats:sub>95<\/jats:sub> values of remimazolam besylate were 0.196\u00a0and 0.239\u2009mg\/kg, respectively, for the procedural sedation of ERCP. The time of MOAA\/S score\u2009\u2264\u20092 was (82.58\u2009\u00b1\u200921.70)\u2009s, and the mean time of awakening was (9.03\u2009\u00b1\u20095.64)\u2009min. Transient hypotension was observed in two patients without medical intervention. The ED<jats:sub>50<\/jats:sub> and ED<jats:sub>95<\/jats:sub> values of remimazolam besylate used in the procedural sedation of ERCP were 0.196\u00a0and 0.239\u2009mg\/kg, and the dose of the medications has definite efficacy and good safety.<\/jats:p>","DOI":"10.1002\/ibra.12072","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T04:49:40Z","timestamp":1668055780000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-2227","authenticated-orcid":false,"given":"Dan\u2010Dan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University  Zunyi Guizhou 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