{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:27:36Z","timestamp":1778786856147,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neurological illness known as a locked\u2010in syndrome is brought on by damage to the brainstem, usually as a consequence of a stroke. It is characterized by total paralysis with intact consciousness and cognitive capacity. The subjective experiences of people with locked\u2010in syndrome are poorly understood. Presently, there is no systematic evaluation developed to describe them. The most compelling resources come from individuals\u2019 own words; however, only a small fraction of these accounts have been explored. When it comes to bioethics, locked\u2010in syndrome protocols are almost completely absent. Investigations on how people with this condition feel about their sense of continuity are of importance. Utilizing the locked\u2010in syndrome to pose questions on embodied cognition and levels of consciousness could serve as a lens through which to examine problems in the phenomenology of neuroparalysis and communication. Care and quality of patients\u2019 lives might be improved by an effort to understand this condition better, and ontological questions like \u201cwhat makes a person a person?,\u201d\u00a0\u201cwhat makes a person appear in continuity?,\u201d\u00a0and \u201cwhat are the dynamics of embodiment and intersubjectivity?\u201d might be better explored through that lens. This article aims to explore some biomedical factors that contribute to locked\u2010in syndrome and offers some prognostic and diagnostic recommendations for this rare condition.<\/jats:p>","DOI":"10.1002\/ibra.12077","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T04:09:56Z","timestamp":1667880596000},"page":"476-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroscience of consciousness in the locked\u2010in syndrome: Prognostic and diagnostic review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-7768","authenticated-orcid":false,"given":"Berenika","family":"Maciejewicz","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Einstein Medical Institute North Palm Beach Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM49941.2020.9313391"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-4917-5_29"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2019.05.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12152-018-9358-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12030769"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2022.100050"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12152-018-9374-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1694694"},{"key":"e_1_2_11_10_1","unstructured":"CorputDVD. Locked in syndrome machine learning classification using sentence comprehension EEG data.arXivpreprint.2020.doi:10.48550\/arXiv.2006.12336"},{"key":"e_1_2_11_11_1","unstructured":"National Organization for Rare Disorders.https:\/\/rarediseases.org"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21507740.2021.1904041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0963180118000154"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12152-019-09409-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059416674842"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12152-018-9375-6"},{"issue":"18","key":"e_1_2_11_17_1","article-title":"Evidence of locked\u2010in\u2010syndrome in pediatric nonfatal drowning: results of a family caregiver survey (P7\u20105.005)","volume":"98","author":"Razaqyar M","year":"2022","journal-title":"Neurology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nc\/niz003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1681064"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00671"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12152-018-9388-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/e22121411"}],"container-title":["Ibrain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.12077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ibra.12077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.12077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T20:57:02Z","timestamp":1702673822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ibra.12077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ibra.12077"],"URL":"https:\/\/doi.org\/10.1002\/ibra.12077","archive":["Portico"],"relation":{},"ISSN":["2313-1934","2769-2795"],"issn-type":[{"value":"2313-1934","type":"print"},{"value":"2769-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"2022-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}