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The aim of this study was to evaluate some cognitive abilities of a group of dyslexic children with IS and to measure and compare the plasma BDNF level to dyslexic children without IS and neurotypical (NT) children. The participants were 60 children with DD (30 in the DD\u2009+\u2009IS group; 30 in the DD group) and 30 NT children. The Irlen reading perceptual scale, the Stanford Binet intelligence scale, 4th ed, the dyslexia assessment test, and the Illinois test of psycholinguistic abilities were used. The BDNF level was measured using the enzyme\u2010linked immunosorbent assay. One\u2010minute\u00a0writing and visual closure deficits were more prevalent, while phonemic segmentation deficits were less prevalent in the DD\u2009+\u2009IS group compared to the DD group. The BDNF level in the DD groups was lower than that in NT children (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Some reading and non\u2010reading tasks were influenced by the presence of a coexisting IS. The reduced BDNF level could play a role in the deficits noticed in the abilities of children with DD.<\/jats:p>","DOI":"10.1002\/ibra.12080","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:38:25Z","timestamp":1669898305000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dyslexia with and without Irlen syndrome: A study of influence on abilities and brain\u2010derived neurotrophic factor level"],"prefix":"10.1002","volume":"9","author":[{"given":"Ehab R.","family":"Abdelraouf","sequence":"first","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"},{"name":"Learning Disability and Neurorehabilitation Research Field, Medical Research Centre of Excellence National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Kilany","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"},{"name":"Pediatric Neurology Research Field, Medical Research Centre of Excellence National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Elhadidy","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Elsaied","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"},{"name":"Learning Disability and Neurorehabilitation Research Field, Medical Research Centre of Excellence National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola M.","family":"Eid","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Field, Medical Research Centre of Excellence National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M.","family":"El\u2010Saied","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"},{"name":"Learning Disability and Neurorehabilitation Research Field, Medical Research Centre of Excellence National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Anwar","sequence":"additional","affiliation":[{"name":"Irlen Egypt Center  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-9327","authenticated-orcid":false,"given":"Neveen H.","family":"Nashaat","sequence":"additional","affiliation":[{"name":"Children with Special Needs Research Department, Medical Research and Clinical Studies Institute National Research Centre Cairo Egypt"},{"name":"Learning Disability and Neurorehabilitation Research Field, Medical Research Centre of Excellence National Research Centre Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2016.04.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1068\/p5045"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1012-5574.199398"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.12.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.07.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.02725"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20210069"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9817.2005.00274.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37753-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1504307"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00363"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_14_1","unstructured":"IrlenHL.Long Self\u2010Test for Irlen Syndrome; 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