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However, chemotherapy\u2010induced peripheral neuropathy (CIPN) is one of the most common long\u2010term toxic reactions in chemotherapy, and the occurrence of CIPN affects patients\u2019 quality of life and can cause interruption of chemotherapy in severe cases, thus reducing the efficacy of chemotherapy. We currently summarize the existing CIPN animal models, including the characteristics of several common animal models such as bortezomib\u2010induced peripheral neuropathy, vincristine\u2010induced peripheral neuropathy, and oxaliplatin\u2010induced peripheral neuropathy. It was found that CIPN may lead to behavioral, histopathological, and neurophysiological changes inducing peripheral neuropathy. However, the mechanism of CIPN has not been fully elucidated, especially the prevention and treatment protocols need to be improved. 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