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Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after cardiac surgery. The etiology and mechanism of POCD are not clear. Neuroinflammation, brain mitochondrial dysfunction, cerebral embolism, ischemia, hypoxia, and other factors are related to the pathogenesis of POCD. There is a close relationship between CPB and POCD, as CPB can cause inflammation, hypoxia and reperfusion injury, and microemboli formation, all of which can trigger POCD. POCD increases medical costs, seriously affects patients' quality of life, and increases mortality. Currently, there is a lack of effective treatment methods for POCD. Commonly used methods include preoperative health management, reducing inflammation response during surgery, preventing microemboli formation, and implementing individualized rehabilitation programs after surgery. Strengthening preventive measures can minimize the occurrence of POCD and its adverse effects.<\/jats:p>","DOI":"10.1002\/ibra.12123","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:04:08Z","timestamp":1692007448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Research progress of postoperative cognitive dysfunction in cardiac surgery under cardiopulmonary bypass"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-5289","authenticated-orcid":false,"given":"Yi\u2010Ming","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Judicial Police Hospital of Guizhou Province  Guiyang 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