{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:13:51Z","timestamp":1771326831859,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["7222083"],"award-info":[{"award-number":["7222083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>A reliable animal model is essential for ischemic stroke research. The implications of the external carotid artery (ECA) transection or common carotid artery (CCA) ligation have been described. Thus, a modified animal model, the CCA\u2010repair model, has been established, and studies have shown that the CCA\u2010repair model has potential advantages over the CCA\u2010ligation model. However, whether the CCA\u2010repair model is superior to the ECA\u2010ligation model remains unclear. Sixty male C57BL\/6 mice were randomly assigned to establish the CCA\u2010repair (<jats:italic>n<\/jats:italic>\u2009=\u200934) or ECA\u2010ligation (<jats:italic>n<\/jats:italic>\u2009=\u200926) models. Cerebral blood flow before middle cerebral artery occlusion (MCAO), immediately after MCAO and reperfusion were monitored and the operation duration, postoperative body weight, and food intake within 7 days, and the number of intraoperative and postoperative deaths within 7 days were recorded in the two models. Modified neurological severity scores and Bederson (0\u20135) scores were used to evaluate postoperative neurological function deficits on Days 1\/3\/5\/7. 2,3,5\u2010Triphenyltetrazolium chloride staining was used to quantify lesion volume on Day 7 after the operation. We found the establishment of the CCA\u2010repair model required a longer total operation duration (<jats:italic>p<\/jats:italic>\u2009=\u20090.0175), especially the operation duration of reperfusion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). However, there was no significant difference in body weight and food intake development, lesion volume and intragroup variability, neurological function deficits, mortality, and survival probability between the two groups. The CCA\u2010repair model has no significant advantage over the ECA\u2010ligation model. The ECA\u2010ligation model is still a better choice for focal cerebral ischemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ibra.12128","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:06:34Z","timestamp":1692651994000},"page":"258-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CCA repair or ECA ligation\u2014Which middle cerebral artery occlusion is better in the reperfusion mouse model?"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-5563","authenticated-orcid":false,"given":"Yue","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"},{"name":"Department of Emergency, Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Ping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Fen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2010Min","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department 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Capital Medical University Beijing China"},{"name":"Department of Emergency, Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135530"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413544"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000083625.54851.9A"},{"issue":"7","key":"e_1_2_11_7_1","first-page":"931","article-title":"An alternative surgical approach reduces variability following filament induction of 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