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Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are two commonly used interventions for acute ischemic stroke, but their effectiveness in improving neurological symptoms and functional outcomes in patients with hemiplegia remains uncertain. The aim of this work was to evaluate the impact of IVT and MT within a 4.5\u2010h time frame on patients with acute ischemic stroke and hemiplegia. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. Relevant studies that assessed the impact of IVT and MT within 4.5\u2010h on hemiplegia in patients with an acute ischemic stroke\u00a0were included. Data were extracted and analyzed to determine the overall effects of these interventions. Most included case reports indicate positive outcomes in terms of neurological symptom improvement and functional recovery in patients with hemiplegia after receiving IVT and MT within the specified time frame. However, the heterogeneity among the patients and the limited use of IVT due to contraindications posed challenges in determining the most effective treatment option. The findings from the included studies demonstrate that both interventions led to a decrease in National Institutes of Health Stroke Scale\u00a0scores, indicating an improvement in neurological symptoms. The results highlight the beneficial effects of early thrombolytic interventions and MT on the neurological status and functional outcomes of patients with an acute ischemic stroke.<\/jats:p>","DOI":"10.1002\/ibra.12146","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T08:05:02Z","timestamp":1705133102000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hemiplegia in acute ischemic stroke: A comprehensive review of case studies and the role of intravenous thrombolysis and mechanical thrombectomy"],"prefix":"10.1002","volume":"10","author":[{"given":"Karen Adriana","family":"Carrillo Navarrete","sequence":"first","affiliation":[{"name":"Instituto de Ingenier\u00eda y Tecnolog\u00eda Universidad Aut\u00f3noma de Ciudad Ju\u00e1rez Ciudad Ju\u00e1rez, Chihuahua M\u00e9xico"},{"name":"Grupo de Nanomedicina, Laboratorio de Integraci\u00f3n de Datos y Evidencia en 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