{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:43:55Z","timestamp":1790383435733,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the efficacy and safety of remimazolam for intraoperative sedation during regional anesthesia. It was a phase II\u2010multicenter, randomized, single\u2010blind, parallel\u2010group, active\u2010controlled clinical trial (No. ChiCTR2100054956). From May 6, 2021 to July 4, 2021, patients were randomly enrolled from 17 hospitals in China. A total of 105 patients aged 18\u201365 years who underwent selective surgery under regional anesthesia were included. Patients received different sedatives with different dosages: 0.1\u2009mg\/kg remimazolam (HR), 0.05\u2009mg\/kg remimazolam (LR), or 1.0\u2009mg\/kg propofol (P) group, followed by a maintenance infusion. Main outcome measures included the efficacy of sedation measured by Modified Observer's Assessment of Alertness\/Sedation Scale (MOAA\/S) levels (1\u20134, 1\u20133, 2\u20133, 3, and 2\u20134) during the sedation procedure (the duration percentage) and incidence of adverse reactions. It showed that the duration percentage of MOAA\/S levels 1\u20134 was 100.0 [8.1]% (median [interquartile range]), 89.9 [20.2]%, 100.0 [7.7]% in the HR, LR, and P groups, respectively. The percentage of patients in the HR, LR, and P groups who achieved MOAA\/S levels 1\u20134 within 3\u2009min after administration was 85.7%, 58.8%, and 82.9%, respectively. However, the time to recovery from anesthesia after withdrawal of sedatives (7.9\u2009\u00b1\u20095.7\u2009min), incidence of anterograde amnesia (75%), and adverse effects were not statistically significant among the three groups. These findings suggest that a loading dose of remimazolam 0.1\u2009mg\/kg followed by a maintenance infusion of 0\u20133\u2009mg\/kg\/h provides adequate sedation for patients under regional anesthesia without increasing adverse reactions.<\/jats:p>","DOI":"10.1002\/ibra.12163","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T11:38:50Z","timestamp":1718537930000},"page":"134-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of remimazolam versus propofol for intraoperative sedation during regional anesthesia: A phase II, multicenter, randomized, active\u2010controlled, single\u2010blind clinical trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-6719","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Huan","family":"Wei","sequence":"additional","affiliation":[{"name":"Graduate School of Education Beijing Foreign Studies University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Surgery, Department of General Surgery West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Surgery, Department of General Surgery West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveva B. da Graca","family":"Cunha","sequence":"additional","affiliation":[{"name":"Hospital Ayres Menezes Sao Tome Sao Tome and Principe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2008.04769.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2006.15.7.20896"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1802-126"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023061"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818fc334"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108838"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.56"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31823f0c28"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01299-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1806"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01316"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.02.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2010.07.016"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(94)00001-K"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01544-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02800-3"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a705ae"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.690875"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15188"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01373-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5276-0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S261997"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2132"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00896-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027808"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199809000-00021"}],"container-title":["Ibrain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.12163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T08:06:59Z","timestamp":1719130019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ibra.12163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/ibra.12163"],"URL":"https:\/\/doi.org\/10.1002\/ibra.12163","archive":["Portico"],"relation":{},"ISSN":["2313-1934","2769-2795"],"issn-type":[{"value":"2313-1934","type":"print"},{"value":"2769-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}