{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:45:11Z","timestamp":1789155911508,"version":"build-2803163510"},"reference-count":184,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ibrain"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a common complication in patients with malignant tumors during chemotherapy. The pathological mechanisms of CIPN remain unclear, and effective preventive and therapeutic strategies are still lacking, posing a major challenge in clinical practice. Aberrant activation of spinal glial cells, particularly microglia and astrocytes, is a key pathological hallmark of CIPN. Evidence from multiple animal models supports a causal link between glial activation and CIPN, suggesting that glial cells may serve as potential therapeutic targets. However, owing to the diversity of chemotherapy agents, the mechanisms of glial activation in CIPN differ and remain insufficiently characterized. This review takes spinal glial activation induced by peripheral nerve injury as its starting point, with a specific focus on microglia and astrocytes. It provides a systematic overview of their roles and mechanisms in CIPN caused by commonly used chemotherapeutic agents. The aim is to deepen understanding of CIPN pathogenesis and provide a foundation for developing targeted therapies.<\/jats:p>","DOI":"10.1002\/ibra.70007","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:15:13Z","timestamp":1764674113000},"page":"65-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanisms of spinal glial activation in chemotherapy\u2010induced peripheral neuropathy: Focus on microglia and astrocytes"],"prefix":"10.1002","volume":"12","author":[{"given":"Long","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital) Dongguan China"},{"name":"Dongguan Key Laboratory of Anesthesia and Organ Protection Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8915-1774","authenticated-orcid":false,"given":"Yonghuai","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Zunyi Medical University Zunyi China"},{"name":"Department of Hematology The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital) Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.02.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01142-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14080991"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040751"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1080888"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2025.1547524"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.033"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12030398"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105957"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.611269"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01450-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.1028653"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26519-x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12310"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1379-y"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02645-2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300539"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2203064"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/011570159X385690250509050208"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.07.026"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002910"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1345811"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070645"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.211"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.11.014"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00032-1"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2025.1548252"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.250566"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/306686a0"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111470"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3016-07.2007"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30252"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu2159"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-023-00685-w"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132083"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001337"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23816"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1524-2"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934314"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1303937"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_912_23"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.11.009"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071799"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S327234"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2868"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.019"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2021.05.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069231185439"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4189"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02489-9"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03244-x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade9931"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI161507"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl6773"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0218-1"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-025-02045-9"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2513-1"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-5-15"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17010044"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14827"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00153"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.04.001"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S415642"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235917"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S241101"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.03.004"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S459757"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02877H"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083927"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23229"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2023.106405"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.110"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.01.011"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1547739"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.04.012"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238138"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2077-x"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgad023"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.22462\/01.02.2022.6"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117515"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060733"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275428"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2016-0194"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11523"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2021.03.142"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0920-4"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2021.3285"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.08.010"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001177"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00778"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01315-w"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.12.002"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0006"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.09.033"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126300"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401277R"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170584"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136512"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168811"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.09.035"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175130"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134624"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156370"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23669"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2025.01.011"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S504873"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.01.005"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.10.011"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1461-0"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8143754"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erae240"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03415-0"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-03814-1"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02098-y"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003433"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.016"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001547"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170814"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1460072"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.10.007"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113010"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01069-8"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.850"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14111500"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05638-9"},{"issue":"5","key":"e_1_2_12_130_1","first-page":"278","article-title":"Characterising vincristine\u2010induced peripheral neuropathy in adults: symptom development and long\u2010term persistent outcomes","volume":"32","author":"Li T","year":"2024","journal-title":"Support Care Cancer: Off J Multinational Assoc Support Care Cancer"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09631-y"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1391-2"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809952"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18160"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00784-7"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117134"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220527120237"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2022.0008"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152882"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09942-w"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17010121"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2022.2069531"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4029694"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.03.013"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110384"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27812"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02127-x"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00532"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105716"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2024.104751"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157039"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83207-8"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110342"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.027"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2024.28.2.145"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115075"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005768"},{"key":"e_1_2_12_158_1","first-page":"3655","article-title":"Fecal microbiota transplantation\u2010mediated rebalancing of the gut\u2010brain axis alleviates cisplatin\u2010induced neuropathic pain","volume":"15","author":"Rani M","year":"2024","journal-title":"ACS Chem Neurosci"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6612009"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-023-00642-7"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202100137"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.04.004"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010919-023603"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111647"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020888"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.05.051"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.05.004"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b22-00861"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910256"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2162244"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16206"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05222-2"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01061-x"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03207-3"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0333-z"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002556"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.626687"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23554"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00219.x"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.03.037"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.08.005"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.646068"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2024.39895"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu377"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3760-2"}],"container-title":["Ibrain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.70007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ibra.70007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ibra.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:41:33Z","timestamp":1781588493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ibra.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":184,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ibra.70007"],"URL":"https:\/\/doi.org\/10.1002\/ibra.70007","archive":["Portico"],"relation":{},"ISSN":["2313-1934","2769-2795"],"issn-type":[{"value":"2313-1934","type":"print"},{"value":"2769-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}