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Psychobiotics are live microorganisms that confer mental health benefits and have emerged as a promising intervention targeting the gut\u2013brain axis. Evidence from preclinical studies demonstrated that psychobiotics can restore neurotransmitter balance by modulating pro\u2010inflammatory cytokines and enhancing the expression of brain\u2010derived neurotrophic factor. However, significant challenges remain, including the limited availability of clinical studies, determining optimal dosages, and understanding the long\u2010term benefits of specific psychobiotic strains and their application in food matrices. This review highlights the findings from recent studies to identify psychobiotics' capability on tryptophan metabolism and their role in facilitating the synthesis of serotonin to propose a mechanistic framework for microbe\u2010driven serotonin. While the eukaryotic pathways of serotonin biosynthesis are well defined, the specific mechanism by which bacteria contribute to this synthesis remains less understood; elucidating this metabolic link is essential. 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