{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:24:44Z","timestamp":1792157084090,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maintenance doses for\u00a0allergen immunotherapy\u00a0(AIT) have been recommended for at least 3 years but little data on long\u2010term efficacy is available depending on AIT duration. To show sustained efficacy 10 years after completion of treatment with depigmented\u2010polymerized house dust mite (dpg\u2010pol HDM) allergen extract in adults with asthma and\/or rhinoconjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients included in a double\u2010blind placebo\u2010controlled AIT study with dpg\u2010pol HDM allergen extract were reviewed at completion of the perennial treatment and 10\u2010year follow\u2010up (10y\u2010FU).\u00a0Change in symptom and rescue medication score was the primary objective. Visual analog scale (VAS), asthma control test (ACT),\u00a0and degree of disease control were the secondary objectives. A comparative analysis between patients who underwent AIT treatment for &lt;3 years and \u22653 years was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 31 patients (mean age 38 years) were available at 10y\u2010FU.\u00a0All had asthma and 29 had rhinoconjunctivitis at baseline. Twenty\u2010three\u00a0patients were treated \u22653 years and 8 for &lt;3 years. Seventeen (55%) patients were asymptomatic at completion of AIT, with significant differences for nasal, conjunctival, and bronchial symptoms (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) compared with baseline only in those patients treated \u22653 years. Nine (52.9%) patients remained completely asymptomatic at 10y\u2010FU, all were treated for \u22653 years. Moreover, significant reduction in the number of patients with rhinitis (<jats:italic>p<\/jats:italic>\u2009=\u2009.0117), conjunctivitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), and bronchial (<jats:italic>p<\/jats:italic>\u2009=\u2009.0005) symptoms was observed at 10y\u2010FU\u00a0compared with baseline only in the \u22653 years\u00a0treated. Ten (32.3%) patients did not require any rescue medication at 10y\u2010FU,\u00a0all had been treated for \u22653 years. ACT at 10y\u2010FU\u00a0showed a good control of asthma (median 23.5; 95% IC[22.0, 25.0]). No significant differences were observed between VAS at end of treatment compared with\u00a0VAS at 10y\u2010FU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sustained clinical efficacy is achieved 10 years after completion of depigmented\u2010polymerized HDM, however, these findings were observed only if patients are treated for at least 3 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1004","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:11:44Z","timestamp":1697199104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["House dust mite subcutaneous immunotherapy has sustained long\u2010term effectiveness on allergic rhinitis and asthma: A 10\u2010year follow\u2010up"],"prefix":"10.1002","volume":"11","author":[{"given":"Elena","family":"Rodriguez\u2010Plata","sequence":"first","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-8262","authenticated-orcid":false,"given":"Ariel","family":"Callero Viera","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-6453","authenticated-orcid":false,"given":"Monica","family":"Ruiz\u2010Garcia","sequence":"additional","affiliation":[{"name":"Medical Affairs and Clinical Department LETI Pharma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Gomez\u2010Cardenosa","sequence":"additional","affiliation":[{"name":"Medical Affairs and Clinical Department LETI Pharma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Nieto","sequence":"additional","affiliation":[{"name":"Medical Affairs and Clinical Department LETI Pharma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Garc\u00eda\u2010Robaina","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70271-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13317"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-018-0176-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13201"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.043"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0268-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00862.x"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"244","article-title":"Significant improvement in symptoms, skin test, and specific bronchial reactivity after 6 months of treatment with a depigmented, polymerized extract of Dermatophagoides pteronyssinus and D. farinae","volume":"13","author":"Ferrer A","year":"2003","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12347"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.02.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14240"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13099"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2009.04.006"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:04:58Z","timestamp":1698912298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/iid3.1004"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1004","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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