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The lung is the major target organ of SARS\u2010CoV\u20102 and some of its variants like Delta and Omicron variant adapted in such a way that these variants can significantly damage this vital organ of the body. These variants raised a few eyebrows as the outbreaks have been seen in the vaccinated population. Patients develop severe respiratory illnesses which eventually prove fatal unless treated early.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Body<\/jats:title><jats:p>Studies have shown that SARS\u2010CoV\u20102 causes the release of pro\u2010inflammatory cytokines such as interleukin (IL)\u20106, IL\u20101\u03b2 and tumor necrosis factor (TNF)\u2010\u03b1 which are mediators of lung inflammation, lung damage, fever, and fibrosis. Additionally, various chemokines have been found to play an important role in the disease progression. A plethora of pro\u2010inflammatory cytokines \u201ccytokine storm\u201d has been observed in severe cases of SARS\u2010CoV\u20102 infection leading to acute respiratory distress syndrome (ARDS) and pneumonia that may prove fatal. To counteract cytokine storm\u2010inducing lung inflammation, several promising immunomodulatory approaches are being investigated in numerous clinical trials. However, the benefits of using these strategies should outweigh the risks involved as the use of certain immunosuppressive approaches might lead the host susceptible to secondary bacterial infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present review discusses promising immunomodulatory approaches to manage lung inflammation in COVID\u201019 cases which may serve as potential therapeutic options in the future and may prove lifesaving.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1020","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:41:44Z","timestamp":1695735704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunomodulatory approaches in managing lung inflammation in COVID\u201019: A double\u2010edge sword"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-9821","authenticated-orcid":false,"given":"Geetika","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-7138","authenticated-orcid":false,"given":"Manish","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Microbiology Punjab Agricultural University  Ludhiana India"},{"name":"Trafford College  Altrincham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AbdulRahman A.","family":"Saied","sequence":"additional","affiliation":[{"name":"Ministry of Tourism and Antiquities, Aswan Office  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetika","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Opthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reetesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, Institute of Applied Sciences and Humanities GLA University  Mathura India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2272","authenticated-orcid":false,"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Allied Health Sciences Daffodil International University  Dhaka Bangladesh"},{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School &amp; 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