{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:49:50Z","timestamp":1791805790196,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore potential risk factors for the occurrence of multiple organ dysfunction syndrome (MODS) in patients with multiple injuries by evaluating neutrophil\u2010to\u2010lymphocyte ratio (NLR)\u2010associated trauma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective case\u2013control study included 95 patients with multiple injuries, who were admitted to our hospital (between January 2018 and December 2020). Clinical data including gender, age, underlying disease, number of injury sites (NIS), injury severity score (ISS), hemoglobin level within 24\u2009h of admission (HL\u201024h), neutrophil count (NC), white blood cell count, platelet count (PC), NLR, <jats:sc>d<\/jats:sc>\u2010dimer level, activated partial thromboplastin time (APTT), complicated shock within 24\u2009h of admission (CS\u201024h), length of stay, as well as prognostic outcome was systematically analyzed. According to MODS occurrence, patients were divided into a MODS group (<jats:italic>n<\/jats:italic>\u2009=\u200927) and a non\u2010MODS group (<jats:italic>n<\/jats:italic>\u2009=\u200968). The risk factors affecting patients with multiple injuries complicated by MODS were identified using univariate and multivariate logistic regression analyses. Candidate risk factors were further analyzed using receiver operating characteristic (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis revealed a significant difference between the MODS and non\u2010MODA groups in terms of NIS, ISS, HL\u201024h, PC, APTT, <jats:sc>d<\/jats:sc>\u2010dimer level, CS\u201024h, NLR, NC, prognostic outcome, and other indicators (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Multivariate logistic regression analysis showed that\u00a0\n<jats:sc>d<\/jats:sc>\u2010dimer levels within 24\u2009h of admission and ISS, NLR, and CS\u201024h were significantly associated with multiple injuries complicated by MODS. Compared with the non\u2010MODS controls, the NLR in the MODS group showed a much higher level and tended to rise with the increase in ISS score, indicating a significant intergroup difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The ROC curve analysis results suggested that the NLR had good sensitivity and specificity for predicting the prognosis of patients with MODS with multiple injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sc>d<\/jats:sc>\u2010dimer level, ISS, NLR, and CS\u201024h are important risk factors for MODS in patients with multiple injuries. Notably, NLR expression may be a good indicator of injury severity and predictor of the occurrence of MODS in patients with multiple injuries. Therefore, assessment of injury severity and coagulation function, active resuscitation, as well as prevention of infection should be emphasized during treatment of multiple injuries, to reduce and prevent the risk of MODS in patients with multiple injuries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1031","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:22:16Z","timestamp":1695734536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neutrophil\u2010to\u2010lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Yong\u2010Ming","family":"He","sequence":"first","affiliation":[{"name":"Department of Emergency Shenzhen Longhua District Center Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Shenzhen Longhua District Center Hospital  Shenzhen China"},{"name":"Department of Emergency The Second People's Hospital of Futian District  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Yi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Emergency The Second People's Hospital of Futian District  Shenzhen China"},{"name":"Department of Public Health Guangdong Medical University Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4372-5702","authenticated-orcid":false,"given":"Qiu\u2010Hong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Emergency Shenzhen Longhua District Center Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000453"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111354"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000779"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001049"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2012.12.009"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2010\u2010rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R","year":"2001","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2006.07.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-014-0392-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001582"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0605"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00154-X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.298"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31825d60e5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.5865"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.e20617"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331494"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"26","article-title":"The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease","volume":"11","author":"Alizade E","year":"2015","journal-title":"Adv Interv Cardiol"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-02065-2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrab032.046"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.07.072"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-019-03463-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000753"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.02.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.982477"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11157"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318230089e"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400899"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231832"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/bs12040091"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2013.03.015"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-019-01264-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-227X-13-S1-S6"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12364"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-012-0227-5"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.55095\/achot2020\/019"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002796"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12568"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31828cc967"},{"issue":"1","key":"e_1_2_11_40_1","article-title":"Correlation between plasma D\u2010dimer level and severity and prognosis in patients admitted at emergency department with trauma","volume":"66","author":"An ZP","year":"2020","journal-title":"Clin Lab"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:19:32Z","timestamp":1696004372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/iid3.1031"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1031","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1031"}}