{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:05:57Z","timestamp":1782821157559,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Graves' disease (GD) is a T cell\u2010mediated organ\u2010specific autoimmune disease. Forkhead box P3 (FoxP3) is an excellent marker for the induction and development of regulatory T cells (Tregs). Recent studies showed that single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>FoxP3<\/jats:italic> gene were associated with the increased susceptibility to several autoimmune diseases. In the present study, we investigated the association of <jats:italic>FoxP3<\/jats:italic> gene polymorphisms with GD in a Southwest Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010stage case\u2010control study was performed in 890 healthy controls (male, 282; female, 608) and 503 patients with GD (male, 138; female, 365). Four SNPs (rs3761548, rs3761549, rs3761547, and rs2280883) were genotyped by the polymerase chain reaction\u2010restriction fragment length polymorphism assay. The <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test was used to compare the genotype distributions and allele frequencies between GD patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first stage, the significantly increased frequencies of the A allele (<jats:italic>p<\/jats:italic>\u2009=\u2009.031, odds ratio [OR]\u2009=\u20091.635) and AA genotype (<jats:italic>p<\/jats:italic>\u2009=\u2009.023, OR\u2009=\u20093.257), together with a significantly decreased frequency of the C allele (<jats:italic>p<\/jats:italic>\u2009=\u2009.031, OR\u2009=\u20090.611) of <jats:italic>F<\/jats:italic>ox<jats:italic>P3<\/jats:italic>\/rs3761548 were found in female patients with GD. None of the other <jats:italic>FoxP3<\/jats:italic> SNPs was associated with GD susceptibility. Subsequent validation and combination of data confirmed the association between <jats:italic>FoxP<\/jats:italic>3\/rs3761548 and the female patients with GD (A allele: <jats:italic>p<\/jats:italic>\u2009&lt; .001, OR\u2009=\u20091.672; AA genotype: <jats:italic>p<\/jats:italic>\u2009=\u2009.005, OR\u2009=\u20092.488; CC genotype: <jats:italic>p<\/jats:italic>\u2009=\u2009.001, OR\u2009=\u20090.622; C allele: <jats:italic>p<\/jats:italic>\u2009&lt; .001, OR\u2009=\u20090.615, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that <jats:italic>F<\/jats:italic>ox<jats:italic>P<\/jats:italic>3\/rs3761548 is significantly associated with female GD patients in a Southwest Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1046","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:23:07Z","timestamp":1697196187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of genetic variations in <i>FoxP3<\/i> gene with Graves' disease in a Southwest Chinese Han population"],"prefix":"10.1002","volume":"11","author":[{"given":"Guiqin","family":"Tan","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Special Key Laboratory of Ocular Diseases of Guizhou Province Zunyi Medical University  Zunyi China"},{"name":"The Second Affiliated Hospital of Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbing","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Special Key Laboratory of Ocular Diseases of Guizhou Province 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