{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:40:14Z","timestamp":1783489214939,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recurrent pregnancy loss (RPL) and pre\u2010eclampsia (PE) are immune\u2010related pregnancy complications that have been linked to CD4<jats:sup>+<\/jats:sup> T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta\u2010analysis aimed to investigate the relationship between interleukin (IL)\u201017 and \u201027 polymorphisms and the susceptibility to RPL and PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All eligible case\u2010control studies published up to February 2023 were identified by searching PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar. The risk of recurrent pregnancy loss and PE associated with the IL\u201017 rs2275913, IL\u201017 rs763780, IL\u201027 rs153109, and IL\u201027 rs17855750 polymorphisms were estimated for each study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis incorporated a total of 13 studies. The overall analysis indicated that IL\u201017 rs2275913, IL\u201017 rs763780, IL\u201027 rs153109, and IL\u201027 rs17855750 polymorphisms were not significantly associated with immune\u2010related pregnancy complications, including RPL and PE. However, when the analysis was stratified by disease type, the IL\u201017 rs2275913 polymorphism was found to be associated with an increased risk of RPL (recessive model AA\/GA\u2009+\u2009GG: OR\u2009=\u20091.68, 95% confidence interval [CI]: 1.13\u20132.49, <jats:italic>p<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IL\u201017 rs763780, IL\u201027 rs153109, and IL\u201027 rs17855750 polymorphisms were not significantly associated with RPL and PE, whereas the IL\u201017 rs2275913 polymorphism was associated with the susceptibility to recurrent miscarriage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1057","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T13:47:34Z","timestamp":1698241654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of IL\u201017 and IL\u201027 polymorphisms with susceptibility to recurrent pregnancy loss and pre\u2010eclampsia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-6372","authenticated-orcid":false,"given":"Yue","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Third Hospital National Clinical Research Center for Obstetrical and Gynecology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Public Health Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Third Hospital National Clinical Research Center for Obstetrical and Gynecology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Third Hospital National Clinical Research Center for Obstetrical and Gynecology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Third Hospital National Clinical Research Center for Obstetrical and Gynecology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University Third Hospital National Clinical Research Center for Obstetrical and Gynecology Beijing 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