{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:01:03Z","timestamp":1771189263002,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This systematic review and meta\u2010analysis aims to investigate the mutual impact of COVID\u201019 and psoriasis to inform clinical practice and future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed the Preferred Reporting Items for Systematic Reviews and Meta\u2010analysis protocol for systematic reviews and searched PubMed, Web of Science, Scopus, and Google Scholar until May 1, 2022. Eligibility criteria included full\u2010text articles in English reporting COVID\u201019 treatment outcomes in psoriasis patients. Studies on animals, letters to editors, non\u2010English studies, and studies with no access to full articles were excluded. Search results were screened and data were extracted by two groups of reviewers with any discrepancies resolved by the senior author. The risk of bias was assessed using ROBINS\u2010I for nonrandomized studies. The hospitalization rate, Intensive Care Unit\u00a0(ICU) admission rate, case fatality rate, odds ratios of COVID\u201019 infection and hospitalization rate in psoriasis patients were extracted and analyzed using random effects analysis to calculate pooled prevalence and odds ratios, as well as to explore heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 1980 records from four databases and included 20 studies after screening and removing duplicates. These studies evaluated 185,000 psoriasis patients and included eight retrospective cohort studies, one case\u2010control study, three cross\u2010sectional studies, and eight case series studies. The impact of the COVID\u201019 pandemic on psoriasis treatment and the outcome of COVID\u201019 infection in psoriasis patients receiving different forms of treatment were evaluated. The pooled data from included studies showed that the incidence rate of COVID\u201019 infection among psoriasis patients was 0.03% (confidence interval [CI]: 0.01\u20130.06), with a pooled odds ratio of 1.97 (CI: 0.69\u20135.60) compared to the general population. The hospitalization rate, ICU admission rate, and case fatality rate for psoriasis patients with COVID\u201019 were 0.17 (CI: 0.10\u20130.31), 0.06 (CI: 0.06\u20130.46), and 0.02 (CI: 0.01\u20130.04), respectively. Additionally, psoriasis patients receiving systemic nonbiologic therapy had a pooled odds ratio of 2.32 (CI: 1.18\u20134.57) for hospitalization compared to those using biologic agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Studies have shown that biologic therapy for psoriasis did not increase the risk of hospitalization due to COVID\u201019 infection and may have even offered some protection. Treatment adherence was higher in psoriasis patients receiving biologic therapies than those receiving conventional therapies. These findings suggest that psoriasis treatment did not negatively impact COVID\u201019 infection and that treatment could be continued on a case\u2010by\u2010case basis during the pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1063","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T12:45:23Z","timestamp":1699361123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A systematic review and meta\u2010analysis of investigating the mutual impact of COVID\u201019 and psoriasis: Focusing on COVID\u201019 course in psoriasis and the opinion on biologics in this setting"],"prefix":"10.1002","volume":"11","author":[{"given":"Nazila","family":"Ghoreishi Amin","sequence":"first","affiliation":[{"name":"Department of Radiology, Keck School of Medicine University of Southern California (USC)  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-0787","authenticated-orcid":false,"given":"Sepehr","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-2441","authenticated-orcid":false,"given":"Najmolsadat","family":"Atefi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC) Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-6206","authenticated-orcid":false,"given":"Farnoosh","family":"Seirafianpour","sequence":"additional","affiliation":[{"name":"Razi Drug Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2749-103X","authenticated-orcid":false,"given":"Sahand","family":"Farhoodi","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC) Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Helath Organization. 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