{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:22Z","timestamp":1786977922902,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapidly progressive glomerulonephritis (RPGN) is clinically manifestations as a rapidly progressive renal failure and pathologically as crescentic and necrotizing lesions with infiltration of inflammatory cells in the glomeruli. Uremic encephalopathy (UE) usually develops in patients who are suffering from acute or chronic renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this article is to provide reference for clinical diagnosis and treatment of renal disease complicated with seizures. Patients Two cases of anti\u2010glomerular basement membrane type rapidly progressive glomerulonephritis complicated with seizures were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Methods<\/jats:title>\n                    <jats:p>In case 1, a 40\u2010year\u2010old woman was hospitalized for the treatment of nausea, anorexia, and fever. On admission, she presented with elevated serum inflammatory indicators, moderate anemia, and advanced acute kidney injury requiring hemodialysis. Her anti\u2010glomerular basement membrane (GBM) antibody in serum and renal tissues was found to be extremely high. She was finally diagnosed with anti\u2010GBM disease. She was treated with a combination of corticosteroid pulse therapy, oral cyclophosphamide and prednisolone, and plasma exchange, while continued to require maintenance hemodialysis for end\u2010stage kidney disease. During treatment, she suddenly suffered blindness, seizure, and consciousness disturbance. She was diagnosed as posterior reversible leukoencephalopathy syndrome by magnetic resonance imaging (MRI). The posterior reversible leukoencephalopathy syndrome subsided quickly after control of her hypertension and reinforcement of immunosuppressive treatment. In case 2, the patient also developed epileptic symptoms on the basis of GBM disease, and was given treatment similar to that of Case 1, so that the epileptic symptoms were controlled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Reversible posterior leukoencephalopathy syndrome, especially when accompanied by cerebral hemorrhage, may lead to irreversible and lethal neurological abnormalities, and nephrologists should, therefore, be aware of the potential risk of reversible posterior leukoencephalopathy syndrome in patients with anti\u2010GBM disease. We can discuss the current two cases in the light of the previous literature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1074","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T20:48:34Z","timestamp":1699476514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antiglomerular basement membrane antibody type rapidly progressive glomerulonephritis with seizures: Two cases and literature review"],"prefix":"10.1002","volume":"11","author":[{"given":"Chongyang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Nephrology Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University Taiyuan China"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Cui","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Affiliated Children's Hospital of Shanxi Medical University, Children's Hospital of Shanxi Shanxi Maternal and Child Health Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University Taiyuan China"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanxi Provincial People's Hospital (Fifth Hospital) of Shanxi Medical University Taiyuan China"},{"name":"Shanxi Provincial Key Laboratory of Kidney Disease Taiyuan 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