{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:47Z","timestamp":1786978007314,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rhino\u2010orbito\u2010cerebral mucormycosis (ROCM) is an opportunistic pathogenic fungal disease caused by the fungus mucor, and it is a life\u2010threatening fungal infection. The ulceration on the skin of the head and neck, accompanied by rhinitis, headache, orbital inflammation, and eyelid edema, should raise a high suspicion of\n                      <jats:italic>Mucor<\/jats:italic>\n                      infection in diabetic patients with inadequately controlled blood glucose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>The clinical data of a patient with ROCM were analyzed retrospectively, and the clinical features were analyzed. The patient was admitted to the hospital with \u201cdiabetic hyperosmotic coma\u201d after presenting with fatigue, poor appetite, and disturbances in consciousness as initial symptoms. After improving relevant examinations, controlling underlying diseases, and administering antifungal treatment, the final clinical outcome was death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ROCM is more prevalent in patients with uncontrolled diabetes and varied clinical manifestations. The characteristic feature is an eschar\u2010like necrosis of the local skin or mucosa. The gold criteria for diagnosis are pathology and fungal culture; imaging examination does not reveal any specific manifestations. Early diagnosis and effective treatment are the keys.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1080","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T04:59:50Z","timestamp":1699505990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case report on clinical features, diagnosis, and treatment of rhino\u2010orbito\u2010cerebral mucormycosis"],"prefix":"10.1002","volume":"11","author":[{"given":"Jie\u2010Qiong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Opthalmology Shanxi Provincial People's Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6352-1174","authenticated-orcid":false,"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Opthalmology Shanxi Provincial People's Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-021-00730-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13078"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"116","article-title":"Manifestation of paroxysmal nocturnal hemoglobinuria as repeated acute kidney injury","volume":"5","author":"Balwani MR","year":"2016","journal-title":"J Nephropharmacol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.202833"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00607-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-021-01109-z"},{"key":"e_1_2_10_8_1","first-page":"20","article-title":"Reconstruction in rhino\u2010orbito\u2010cerebral mucormycosis survivors: a systematic review","volume":"22","author":"Cheruvu VPR","year":"2022","journal-title":"Eplasty"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5506"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02920-20"},{"issue":"6","key":"e_1_2_10_11_1","first-page":"517","article-title":"Analysis of the current situation of mucormycosis and the application of PCR technology in its diagnosis","volume":"17","author":"Yan XY","year":"2022","journal-title":"Chinese J Mycol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6809-20"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"116","article-title":"Interpretation of the 2019 european guidelines for the diagnosis and treatment of mucor disease","volume":"16","author":"Liang GZ","year":"2021","journal-title":"Chinese J Mycol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"},{"issue":"6","key":"e_1_2_10_15_1","first-page":"427","article-title":"Research progress of a new antifungal drug, xaconazole","volume":"45","author":"Jiang YK","year":"2021","journal-title":"Progress in Pharmaceut Sci"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.076463"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T06:38:55Z","timestamp":1703572735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/iid3.1080"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1080","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1080"}}