{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:21:39Z","timestamp":1771600899046,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274481"],"award-info":[{"award-number":["82274481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the differences of clinical characteristics, laboratory findings, and the long\u2010term outcomes in patients with anti\u2010synthetase syndrome (ASS) of different anti\u2010aminoacyl\u2010transfer RNA synthetase antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 119 patients with ASS, and the clinical characteristics and laboratory findings were collected. Additionally, multivariate COX regression analysis was performed to estimate the risk factors of prognosis in patients with ASS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of interstitial lung disease (ILD) reached 93.3% in our cohort, of 28 (23.5%) was classified as rapidly progressive (RP)\u2010ILD. The highest incidence of RP\u2010ILD was 36.4% in the PL12 group of ASS patients. The ILD group was characterized by an older age, a lower prevalence of V sign, and a higher prevalence of pulmonary symptoms when contrasted with the non\u2010ILD group. There were statistical differences of clinical significance in arthritis, myositis, mechanic's hands, triad, shawl sign, V sign, and Raynaud's phenomenon among the four subgroups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Additionally, the prevalence rates of arthritis, myositis, mechanic's hands, triad, and V sign in the anti\u2010Jo1 antibody\u2010positive group were significantly higher than anti\u2010Jo1 antibody\u2010negative patients with ASS (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Multivariate Cox regression analysis showed mechanic's hands (odds ratio [OR]\u2009=\u20096.47, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), anti\u2010nuclear antibodies (ANA) (OR\u2009=\u20092.13, <jats:italic>p<\/jats:italic>\u2009=\u2009.026), ILD (OR\u2009=\u200910.50, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and V sign (OR\u2009=\u20090.30, <jats:italic>p<\/jats:italic>\u2009=\u2009.007) were independent factors affecting the prognosis of patients with ASS. The incidences of RP\u2010ILD, arthritis, myositis, triad, mechanic's hands, and shawl sign were more frequent in the anti\u2010Ro52 antibody\u2010positive group than the anti\u2010Ro52 antibody\u2010negative patients with ASS (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with ASS accompanied with ILD are highly prevalent. Mechanic's hands, ANA, and ILD may be a potential biomarker for predicting a poor prognosis in patients with ASS. Additionally, the detection of the anti\u2010Ro52 antibody provides valuable insights for managing and predicting disease progression and long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1085","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:51:40Z","timestamp":1700279500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and prognostic analysis of idiopathic inflammatory myopathy with positive anti\u2010aminoacyl\u2010tRNA synthetase antibodies: A single center experience"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-4804","authenticated-orcid":false,"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong 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Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong 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