{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:05:47Z","timestamp":1759190747373,"version":"3.44.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>To investigate the frequency and clinical relevance of an extended autoantibody profile in patients with systemic sclerosis\u00a0(SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, serum from 100 consecutive patients was subjected to indirect immunofluorescence (IIF)\u00a0(HEp\u201020\u201010\/primate liver mosaic) and Systemic Sclerosis Profile by EUROIMMUN\u00a0to evaluate anti\u2010nuclear antibodies\u00a0(ANA) and autoantibodies against 13 different autoantibodies in patients with SSc less than 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three of 100 patients were positive for ANA by\u00a0IIF. Fifty\u2010three patients showed single positivity, 26 anti\u2010topoisomerase antibodies (anti\u2010Scl70 ab), 16 anticentromere antibodies (ACAs), six anti\u2010RNA polymerase III antibodies (anti\u2010RNAPIII ab), one anti\u2010Ku antibody, one anti\u2010PM\/Scl100 antibody, two anti\u2010PM\/Scl75 antibodies, one anti\u2010Ro52 antibody, whereas 32 patients had multiple autoantibody positivities. Among classic SSc\u2010specific autoantibodies, anti\u2010Scl70 and anti\u2010RNAPIII abs showed the highest cooccurrence (<jats:italic>n<\/jats:italic>\u2009=\u20094). One patient was simultaneously positive for anti\u2010RNAPIII ab and ACA, and one was positive for ACA and anti\u2010Scl70 ab. The clinical features were not statistically different between single and multiple autoantibody\u2010positivity for classic SSc\u2010specific autoantibodies (ACA, anti\u2010Scl70 ab, and anti\u2010RNAPIII ab), except for digital ulcer in the multiantibody positive ACA group (<jats:italic>p<\/jats:italic>\u2009=\u2009.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our results, coexpression of autoantibodies is not uncommon in SSc patients. Although autoantibodies specific to SSc in early disease show generally known clinical features, it remains to be investigated how the coexpression of autoantibodies will affect clinical presentation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1089","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:55:42Z","timestamp":1702446942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extended autoantibody panel in Turkish patients with early\u2010stage systemic sclerosis: Coexpressions and their influences on clinical phenotypes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-2032","authenticated-orcid":false,"given":"Duygu","family":"Temiz Karada\u011f","sequence":"first","affiliation":[{"name":"Department of Rheumatology Faculty of Medicine, Kocaeli University  Kocaeli 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