{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:47Z","timestamp":1786978007473,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was designed to analyze the structural characteristics of the intestinal flora of elderly Uygur patients with sarcopenia, thereby providing new ideas for clinical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Firstly, fecal samples were collected from 40 elderly Uygur patients with sarcopenia (Sarcopenia group) and 40 healthy people (Control group). Next, significant differences in the intestinal flora between the two groups were analyzed based on 16S rDNA high\u2010throughput sequencing. The linear discriminant analysis effect size (LEfSe) was used to estimate the magnitude of the effect of each component (species) abundance on the differential effect. Additionally, an analysis was also performed on the relationship between the intestinal flora and the cytokines in the peripheral blood of patients with sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results of \u03b2 diversity showed that there were differences in the structure of the intestinal flora between the two groups. Besides, the phylum level of intestinal flora between the two groups was not significantly different. However, the difference was significant in the intestinal flora at the order, family, and genus levels between the two groups. Among them,\n                      <jats:italic>Lachnoclostridium, Photobacterium, Anaerobic Bacillus, Hydrogenophilus<\/jats:italic>\n                      , and\n                      <jats:italic>Eubacterium<\/jats:italic>\n                      were enriched in the Sarcopenia group;\n                      <jats:italic>Prevotella 9, Firmicutes FCS020 group, Streptobacillus, Aggregatibacter, Corynebacterium, Clostridium Difficile<\/jats:italic>\n                      , and\n                      <jats:italic>Haloanaerobium<\/jats:italic>\n                      were enriched in the Control group. The LEfSe outcomes further showed that\n                      <jats:italic>Lachnoclostridium<\/jats:italic>\n                      was highly enriched in the Sarcopenia group;\n                      <jats:italic>Prevotella 9<\/jats:italic>\n                      and\n                      <jats:italic>Firmicutes FCS020<\/jats:italic>\n                      group were significantly enriched in the Control group. Furthermore, the relative abundance of\n                      <jats:italic>Lachnoclostridium<\/jats:italic>\n                      and\n                      <jats:italic>Streptobacillus<\/jats:italic>\n                      were significantly different in patients with high and low IL\u20106 levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, Lachnoclostridium is significantly enriched in the intestines of elderly Uygur patients with sarcopenia; the increase in Lachnoclostridium abundance and the decrease in Streptobacillus abundance are associated with high levels of IL\u20106. Therefore, abnormal intestinal flora is related to inflammatory reflexes in patients with sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1097","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T09:04:20Z","timestamp":1705914260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of intestinal flora in elderly Uygur patients with sarcopenia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0102-0991","authenticated-orcid":false,"given":"Zimei","family":"Shan","sequence":"first","affiliation":[{"name":"People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Cheng","sequence":"additional","affiliation":[{"name":"People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 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