{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:11:50Z","timestamp":1785856310382,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070819"],"award-info":[{"award-number":["82070819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>B\u2010cell activating factor (BAFF) is a key regulator of primary Sj\u00f6gren's syndrome (pSS), which is characterized by B\u2010lymphocyte hyperactivity. BAFF, also known as tumor necrosis factor ligand superfamily member 13B, is encoded by <jats:italic>TNFSF13B<\/jats:italic>. This study aimed to explore the possible relationships between five single\u2010nucleotide polymorphisms (SNPs) of <jats:italic>TNFSF13B<\/jats:italic> (rs9514827, rs1041569, rs9514828, rs1224141, and rs12583006) and pSS susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the following databases for articles on <jats:italic>TNFSF13B<\/jats:italic> polymorphism and pSS published up to January 2023: PubMed, Cochrane, Elsevier, Web of Science, CNKI, CQVIP, and WanFang. The odds ratios (with 95% confidence intervals) of genotypes and SNP alleles of <jats:italic>TNFSF13B<\/jats:italic> were investigated in patients with pSS to determine their relationships with pSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This meta\u2010analysis employing the fixed\u2010effect model comprised three studies of pSS patients and randomly selected healthy controls (HCs), revealing statistically significant relationships between pSS susceptibility and two SNPs: rs1041569 and rs12583006. Because rs1041569 was not in Hardy\u2010Weinberg equilibrium in the HC group, it was eliminated from the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polymorphisms in the BAFF (<jats:italic>TNFSF13B<\/jats:italic>) gene were related to vulnerability to pSS among pSS patients and HCs alike. The SNP rs12583006 was significantly related to pSS susceptibility in pSS patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1103","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:34:55Z","timestamp":1701866095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between <i>TNFSF13B<\/i> polymorphisms and primary Sj\u00f6gren's syndrome susceptibility in primary Sj\u00f6gren's syndrome patients: A meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-9682","authenticated-orcid":false,"given":"Anhao","family":"Zheng","sequence":"first","affiliation":[{"name":"Medical Integration and Practice Center Cheeloo College of Medicine, Shandong University  Jinan China"},{"name":"Department of Rheumatology and Immunology Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University  Jinan 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