{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:22Z","timestamp":1786977922821,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071832"],"award-info":[{"award-number":["82071832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The transcription factor LIM\u2010only protein 4 (LMO4) is overexpressed in the psoriatic epidermis and regulates keratinocyte proliferation and differentiation. High LMO4 expression levels are induced by interleukin\u201023 (IL\u201023) to activate the AKT\/STAT3 signaling pathway. Interleukin\u20106 (IL\u20106) is mainly involved in regulating T cell functions and development in patients with psoriasis. However, whether LMO4 expression is regulated by IL\u20106 remains unclear. Therefore, the purpose of this study is to explore the role and molecular mechanisms of IL\u20106 in regulating LMO4 expression. The interleukin\u20106 (IL\u20106) levels in human plasma were determined using a chemiluminescence immunoassay system. A psoriasis\u2010like mouse model was established using imiquimod induction. Epidermal keratinocytes (HaCaT) were cultured in defined keratinocyte\u2010serum\u2010free medium and stimulated by IL\u20106 alone or with inhibitors. The proteins of interest were detected using western blot analysis, immunofluorescence, and immunohistochemistry. The 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine assay was used to detect cell proliferation. The results revealed that IL\u20106 levels were markedly increased in the plasma of patients with psoriasis, compared to healthy control. The high expression of LMO4 was consistent with high levels of IL\u20106, p\u2010AKT, and p\u2010STAT3 in the lesions of both psoriasis patients and imiquimod\u2010induced psoriasis\u2010like mice. IL\u20106 activates the AKT\/STAT3 signaling pathway, followed by LMO4 high\u2010expression in HaCaT cells. IL\u20106 induces HaCaT proliferation and differentiation via AKT\/STAT3 signaling pathway activation. We think that the high expression of LMO4 in psoriatic keratinocytes requires IL\u20106 to activate the AKT\/STAT3 signaling pathway and leads to epidermal keratinocytes abnormal proliferation and differentiation.<\/jats:p>","DOI":"10.1002\/iid3.1104","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:33:15Z","timestamp":1701865995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pro\u2010inflammatory cytokine IL\u20106 regulates LMO4 expression in psoriatic keratinocytes via AKT\/STAT3 pathway"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-9866","authenticated-orcid":false,"given":"Zhenzhen","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences Anhui Medical University  Hefei 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