{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:37:52Z","timestamp":1785220672136,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Toxoplasma gondii<\/jats:italic> infection is considered as one of the most important opportunistic infections and cause of death in HIV patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 334\u00a0HIV\u00a0positive patients were included. The molecular test was performed by the restriction fragment length polymorphism\u2013polymerase chain reaction method. Allelic frequency, haplotype analyses, and linkage disequilibrium were calculated. The odds ratio was calculated. The linear regression model was used to analysis of interleukin (IL)\u201017A, IL\u201017F, and IL\u20106 single\u2010nucleotide polymorphism genotypes in HIV patients with and without toxoplasmosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 95 tested'patients (28.4%) were positive for toxoplasmosis. The risk of <jats:italic>toxoplasma<\/jats:italic> infection in the current study did not correlate with IL\u201017 and IL\u20106 polymorphism and the risk of contracting <jats:italic>toxoplasma<\/jats:italic> was also not significantly correlated in this study. There was no association between the frequency of alleles and the risk of toxoplasma infection in IL\u201017 haplotype analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study revealed that there were significant differences in the serum levels of IL\u20106 and IL\u201017A, but not IL\u201017F, between the case and control groups in various genetic models. However, these polymorphisms did not show a significant relationship with toxoplasma infection in HIV\u2010positive patients. This study represents the first investigation in Iran to explore the role of IL\u20106 and IL\u201017 polymorphisms in toxoplasma infection among HIV\u2010positive patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1117","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:21:06Z","timestamp":1704896466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of polymorphism of IL\u201017A, IL\u201017F, and IL\u20106 with <i>Toxoplasma gondii<\/i> infection susceptibility in <b>HIV\/AIDS<\/b> patients in Shiraz, southern Iran"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-2563","authenticated-orcid":false,"given":"Maryam","family":"Nejabat","sequence":"first","affiliation":[{"name":"HIV\/AIDS Research Center, Institute of Health Shiraz University of Medical Sciences  Shiraz 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