{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:03:55Z","timestamp":1791453835834,"version":"4.3.3"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin\u201022 (IL\u201022) is an important cytokine in the intestinal environment. IL\u201022 is mainly produced by immune cells and targeted at nonimmune cells such as epithelial and stromal cells in a broad array of tissues such as \u2010but not restricted to\u2010 the liver and adipose tissue. IL\u201022 therefore connects immune functions with metabolic functions of the host, and since it is induced by the microbiota, connects host functioning to the outside environment. IL\u201022 induces epithelial cell proliferation aiding in rapid epithelium regeneration and wound healing. Additionally, IL\u201022 activates antiapoptotic genes and DNA damage response pathways, enhancing epithelial cell survival. Recently, it has also been shown that IL\u201022 induces Paneth cell differentiation in humans. However, IL\u201022 can also contribute to intestinal epithelium damage and reduces microbial diversity in the intestine directly or indirectly by inducing excessive antimicrobial peptide production by epithelial cells. Moreover, IL\u201022 enhances angiogenesis and may therefore support tumorigenesis in the intestine. In conclusion, it appears that whether IL\u201022 has a beneficial or harmful effect in the mammalian intestine largely depends on its regulation. This review aims to provide a comprehensive overview of the current literature and emphasizes that IL\u201022 signaling outcome depends on the timing and duration of IL\u201022 production, the presence of it regulators such as IL\u201022BP, and the specific location of the cytokine production in the gastrointestinal tract.<\/jats:p>","DOI":"10.1002\/iid3.1144","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T07:24:26Z","timestamp":1708068266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The role of interleukin\u201022 in mammalian intestinal homeostasis: Friend and foe"],"prefix":"10.1002","volume":"12","author":[{"given":"Hedi\u2010Britt","family":"Klotskova","sequence":"first","affiliation":[{"name":"Host Microbe Interactomics, Animal Sciences Group Wageningen University and Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Kidess","sequence":"additional","affiliation":[{"name":"Host Microbe Interactomics, Animal Sciences Group Wageningen University and Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adria L.","family":"Nadal","sequence":"additional","affiliation":[{"name":"Host Microbe Interactomics, Animal Sciences Group Wageningen University and Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-0552","authenticated-orcid":false,"given":"Sylvia","family":"Brugman","sequence":"additional","affiliation":[{"name":"Host Microbe Interactomics, Animal Sciences Group Wageningen University and Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.898326"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/la.2009.009112"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10208"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2020.10.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112123"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.11.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119195"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700152"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.643973"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100320"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.20"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0131-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201379"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3721"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16460"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.09.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11743"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.06.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7602951"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0899-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358474"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.11.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121180"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-023-04806-z"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120006916"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1341"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2187575"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02335-18"},{"issue":"3","key":"e_1_2_7_32_1","first-page":"823","article-title":"A secondary metabolite of Brassicales, 1\u2010methoxy\u20103\u2010indolylmethyl glucosinolate, as well as its degradation product, 1\u2010methoxy\u20103\u2010indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells","volume":"88","author":"Schumacher F","year":"2014","journal-title":"Arch Toxicol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13438"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.071"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.33"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844530"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102149"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006672114184"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0252-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.605463"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2017.10.003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318483"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.028"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33331-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-59"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.28"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11535"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766586"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-018-9658-x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25437"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.11.003"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01486-1"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0258-z"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.011"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000047117"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.1144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:10:23Z","timestamp":1788959423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/iid3.1144"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1144","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.170664280.05572546\/v1","asserted-by":"object"}]},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1144"}}