{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:53:33Z","timestamp":1792040013679,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam & Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n Myeloperoxidase (MPO)\u00a0has been identified as a mediator in various inflammatory diseases. Bacterial infection of the intestine and hypoxia can both lead to inflammatory responses, but the role of MPO in these phenomena remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n By building the MPO\n \u2010\/\u2010<\/jats:sup>\n mice, we evaluated relevant inflammatory factors and tissue damage in mice with intestinal\n Citrobacter rodentium<\/jats:italic>\n infection and hypoxia. The body weight and excreted microorganisms were monitored. Intestinal tissues were collected 7 days after bacterial infection under hypoxia to undergo haematoxylin\u2010eosin staining and assess the degree of pathological damage. ELISA assays were performed to quantify the serum levels of TNF\u2010\u03b1, IFN\u2010\u03b3, IL\u20106, and IL\u20101\u03b2 inflammatory cytokines. PCR, WB, and IF assays were conducted to determine the expression of chemokines MCP1, MIP2, and KC in the colon and spleen.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n C. rodentium<\/jats:italic>\n infection and hypoxia caused weight loss, intestinal colitis, and splenic inflammatory cells active proliferation in wild\u2010type mice. MPO deficiency alleviated this phenomenon. MPO\n \u2010\/\u2010<\/jats:sup>\n mice also displayed a significant decline in bacteria clearing ability. The level of TNF\u2010\u03b1 in the serum and spleen was both lower in MPO\n \u2010\/\u2010<\/jats:sup>\n hypoxia\n C. rodentium<\/jats:italic>\n \u2010infected mice than that in wild\u2010type mice. The chemokines expression levels of MIP2, KC,\u00a0and MCP1 in the spleen and colon of each bacterial infected group were significantly increased (\n p<\/jats:italic>\n \u2009<\u2009.05), while in hypoxia, the factors in the spleen and colon were decreased (\n p<\/jats:italic>\n \u2009<\u2009.05). MPO deficiency was found to lower the levels of these chemokines compared with wild\u2010type mice.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MPO plays an important role of the inflammatory responses in infectious enteritis and hypoxia in mice, and the loss of MPO may greatly reduce the body's inflammatory responses to fight diseases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/iid3.1157","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T07:38:30Z","timestamp":1706859510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of myeloperoxidase on inflammatory responses with hypoxia in\n Citrobacter rodentium<\/i>\n \u2010infectious mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Medical College Qinghai University Xining Qinghai China"},{"name":"Research Centre for High Altitude Medicine, Research Centre for High Altitude Medicine Qinghai University Xining Qinghai China"},{"name":"The Key Laboratory of High\u2010Altitude Medical Application of Qinghai Province Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Medical College Qinghai University Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Centre for High Altitude Medicine, Research Centre for High Altitude Medicine Qinghai University Xining Qinghai China"},{"name":"The Key Laboratory of High\u2010Altitude Medical Application of Qinghai Province Xining Qinghai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-5562","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Medical College Qinghai University Xining Qinghai China"},{"name":"Research Centre for High Altitude Medicine, Research Centre for High Altitude Medicine Qinghai University Xining Qinghai China"},{"name":"The Key Laboratory of High\u2010Altitude Medical Application of Qinghai Province Xining Qinghai 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