{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:41:15Z","timestamp":1769053275789,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current vaccines against COVID\u201019 effectively reduce morbidity and mortality and are vitally important for controlling the pandemic. Between December 2020 and February 2021, adenoviral vector vaccines such as ChAdOx1 (AstraZeneca\u2010Oxford) were put in use. Recent reports demonstrate robust serological responses to a single dose of messenger RNA vaccines in individuals previously infected with SARS\u2010CoV\u20102. We aimed to study the association between previous COVID\u201019 infection and antibody levels after a single dose of ChAdOx1 nCoV\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on 657 individuals who were either convalescent or SARS\u2010CoV\u20102 naive and had received one dose of ChAdOx1 (AstraZeneca). A questionnaire was used to collect data on age, sex, and self\u2010reported history of COVID\u201019 infection. We then compared the average levels of immunoglobulin G (IgG) between the previously infected and COVID\u201019\u2010naive participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared the antibody responses of individuals with confirmed prior COVID\u201019 infection with those of individuals without prior evidence of infection. The mean antibody levels in those who reported no history of COVID\u201019 infection were substantially lower than in those who were previously infected, in both males and females. Sex\u2010related differences were observed when we compared antibody levels between men and women. In males, anti\u2010S IgG antibody levels were higher in those who had been previously infected (156.1 vs. 87.69\u2009AU\/mL, <jats:italic>p<\/jats:italic>\u2009=\u2009.009), compared with the same pattern was observed in females (113.5 vs. 90.69\u2009AU\/mL, <jats:italic>p<\/jats:italic>\u2009=\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous COVID\u201019 infection is associated with higher levels of SARS\u2010CoV\u20102 antibodies following ChAdOx1 (AstraZeneca) vaccination. Our finding supports the notion that a single dose of ChAdOx1 nCoV\u201019 administered post\u2010SARS\u2010CoV\u20102 infection serves as an effective immune booster. This provides a possible rationale for a single\u2010dose vaccine regimen for previously infected individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1159","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T11:44:36Z","timestamp":1705664676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single ChAdOx1 nCoV\u201019 dose elicits stronger immune response in previously infected individuals than in SARS\u2010CoV2 naive persons"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-8423","authenticated-orcid":false,"given":"Fawzi","family":"Ebrahim","sequence":"first","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Alboueishi","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-0215","authenticated-orcid":false,"given":"Inas M.","family":"Alhudiri","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah Al","family":"Tabal","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Lamami","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Al Dwigen","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sondos","family":"Ashleb","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Ejenfawi","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed B.","family":"Milad","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayat","family":"Rhoumah","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8613-4625","authenticated-orcid":false,"given":"Salah Edin","family":"El Meshri","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-5937","authenticated-orcid":false,"given":"Adam","family":"Elzagheid","sequence":"additional","affiliation":[{"name":"Departement\/Molecular Diagnostic Group, Cells and Tissue Culture Libyan Biotechnology Research Center Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO. The COVID\u201019 candidate vaccine landscape. February 16 2021. 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