{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:40:23Z","timestamp":1790563223475,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation\u2010induced lung injury (RILI) is a common consequence of thoracic radiation therapy that lacks effective preventative and treatment strategies. Dihydroartemisinin (DHA), a derivative of artemisinin, affects oxidative stress, immunomodulation, and inflammation. It is uncertain whether DHA reduces RILI. In this work, we investigated the specific mechanisms of action of DHA in RILI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four C57BL\/6J mice were randomly divided into four groups of six mice each: Control group, irradiation (IR) group, IR\u2009+\u2009DHA group, and IR\u2009+\u2009DHA\u2009+\u2009Brusatol group. The IR group received no interventions along with radiation treatment. Mice were killed 30 days after the irradiation. Morphologic and pathologic changes in lung tissue were observed with hematoxylin and eosin\u00a0staining. Detection of hydroxyproline levels for assessing the extent of pulmonary fibrosis. Tumor necrosis factor \u03b1 (TNF\u2010\u03b1), transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2), glutathione peroxidase (GPX4), Nuclear factor erythroid 2\u2010related factor 2 (Nrf2), and heme oxygenase\u20101 (HO\u20101) expression in lung tissues were detected. In addition, mitochondrial ultrastructural changes in lung tissues were also observed, and the glutathione (GSH) content in lung tissues was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DHA attenuated radiation\u2010induced pathological lung injury and hydroxyproline levels. Additionally, it decreased TNF\u2010\u03b1 and TGF\u2010\u03b2 after irradiation. DHA may additionally stimulate the Nrf2\/HO\u20101 pathway. DHA upregulated GPX4 and GSH levels and inhibited cellular ferroptosis. Brusatol reversed the inhibitory effect of DHA on ferroptosis and its protective effect on RILI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DHA modulated the Nrf2\/HO\u20101 pathway to prevent cellular ferroptosis, which reduced RILI. Therefore, DHA could be a potential drug for the treatment of RILI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1175","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:28:06Z","timestamp":1707276486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Therapeutic potential of dihydroartemisinin in mitigating radiation\u2010induced lung injury: Inhibition of ferroptosis through Nrf2\/HO\u20101 pathways in mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Xin","family":"Ning","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7167-6074","authenticated-orcid":false,"given":"Shixiong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Guangxi Medical University Cancer Hospital  Nanning Guangxi Zhuang Autonomous Region 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